The influence of five monoamine genes on trajectories of depressive symptoms across adolescence and young adulthood

Daniel E. Adkins, Jonathan Kyle Daw, Joseph L. Mcclay, Edwin J.C.G. Van Den Oord

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The influence of five monoamine candidate genes on depressive symptom trajectories in adolescence and young adulthood were examined in the Add Health genetic sample. Results indicated that, for all respondents, carriers of the dopamine receptor D4 5-repeat allele were characterized by distinct depressive symptom trajectories across adolescence and early adulthood. Similarly, for males, individuals with the monoamine oxidase A 3.5-repeat allele exhibited unique depressive symptom trajectories. Specifically, the trajectories of those with the dopamine receptor D4 5-repeat allele were characterized by rising levels in the transition to adulthood, while their peers were experiencing a normative drop in depressive symptom frequency. Conversely, males with the monoamine oxidase A 3.5-repeat allele were shown to experience increased distress in late adolescence. An empirical method for examining a wide array of allelic combinations was employed, and false discovery rate methods were used to control the risk of false positives due to multiple testing. Special attention was given to thoroughly interrogate the robustness of the putative genetic effects. These results demonstrate the value of combining dynamic developmental perspectives with statistical genetic methods to optimize the search for genetic influences on psychopathology across the life course.

Original languageEnglish (US)
Pages (from-to)267-285
Number of pages19
JournalDevelopment and Psychopathology
Volume24
Issue number1
DOIs
StatePublished - Feb 1 2012

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Alleles
Dopamine D4 Receptors
Depression
Monoamine Oxidase
Genes
Psychopathology
Health

All Science Journal Classification (ASJC) codes

  • Developmental and Educational Psychology
  • Psychiatry and Mental health

Cite this

Adkins, Daniel E. ; Daw, Jonathan Kyle ; Mcclay, Joseph L. ; Van Den Oord, Edwin J.C.G. / The influence of five monoamine genes on trajectories of depressive symptoms across adolescence and young adulthood. In: Development and Psychopathology. 2012 ; Vol. 24, No. 1. pp. 267-285.
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The influence of five monoamine genes on trajectories of depressive symptoms across adolescence and young adulthood. / Adkins, Daniel E.; Daw, Jonathan Kyle; Mcclay, Joseph L.; Van Den Oord, Edwin J.C.G.

In: Development and Psychopathology, Vol. 24, No. 1, 01.02.2012, p. 267-285.

Research output: Contribution to journalArticle

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