The influence of level of spinal cord injury on adipose tissue and its relationship to inflammatory adipokines and cardiometabolic profiles

Gary J. Farkas, Ashraf S. Gorgey, David R. Dolbow, Arthur S. Berg, David R. Gater

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective: Level of injury (LOI) and the role of adipose tissue and its proinflammatory adipokines in cardiometabolic dysfunction following spinal cord injury (SCI) remains poorly understood. We aim to examine the influence of LOI on adipose tissue and its relationship to proinflammatory adipokines and cardiometabolic profiles following SCI. Design: Cross sectional and correlational study. Setting: Clinical hospital and academic setting. Participants: Forty-seven individuals with chronic motor complete SCI (age 43.8±11.5 y, BMI: 27.3±5.3) were classified as having tetraplegia (TSCI; n=12) or paraplegia (PSCI; n=35). Intervention: Non applicable. Outcome Measures: Visceral (VAT) and subcutaneous (SAT) adipose tissue volumes were measured using magnetic resonance imaging. Proinflammatory adipokines (tumor neurosis factor-α, interleukin-6 (IL-6), plasminogen activatable inhibitor-1, thrombin-activatable fibrinolysis inhibitor, and high-sensitivity c-reactive protein) and cardiovascular, carbohydrate, and lipid profiles were assessed according to standard techniques. Results: VAT volume was greater in TSCI versus PSCI (p=0.042); however, after covarying for age this significance was lost (p>0.05). IL-6 was significantly elevated in TSCI (p<0.05), while other markers of inflammation generally were elevated, but did not reach statistical significance (p>0.05). Systolic blood pressure and total cholesterol were significantly lower in TSCI (p<0.05), while fasting glucose was significantly lower in PSCI (p<0.05). A number of proinflammatory adipokines and cardiometabolic markers significantly correlated with adipose tissue depots by LOI (p<0.05). Conclusion: The results show that LOI does not influence the distribution of adipose tissue, but does influence proinflammatory adipokines and cardiometabolic profiles following SCI. Further research is needed to evaluate impact of lean body mass on these findings.

Original languageEnglish (US)
Pages (from-to)407-415
Number of pages9
JournalJournal of Spinal Cord Medicine
Volume41
Issue number4
DOIs
StatePublished - Jul 4 2018

Fingerprint

Adipokines
Spinal Cord Injuries
Adipose Tissue
Wounds and Injuries
Interleukin-6
Carboxypeptidase B2
Blood Pressure
Quadriplegia
Neurotic Disorders
Paraplegia
Plasminogen
Subcutaneous Fat
Fasting
Cross-Sectional Studies
Cholesterol
Carbohydrates
Magnetic Resonance Imaging
Outcome Assessment (Health Care)
Lipids
Glucose

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

Cite this

@article{29a3b734a6e1472a848caab996d971ba,
title = "The influence of level of spinal cord injury on adipose tissue and its relationship to inflammatory adipokines and cardiometabolic profiles",
abstract = "Objective: Level of injury (LOI) and the role of adipose tissue and its proinflammatory adipokines in cardiometabolic dysfunction following spinal cord injury (SCI) remains poorly understood. We aim to examine the influence of LOI on adipose tissue and its relationship to proinflammatory adipokines and cardiometabolic profiles following SCI. Design: Cross sectional and correlational study. Setting: Clinical hospital and academic setting. Participants: Forty-seven individuals with chronic motor complete SCI (age 43.8±11.5 y, BMI: 27.3±5.3) were classified as having tetraplegia (TSCI; n=12) or paraplegia (PSCI; n=35). Intervention: Non applicable. Outcome Measures: Visceral (VAT) and subcutaneous (SAT) adipose tissue volumes were measured using magnetic resonance imaging. Proinflammatory adipokines (tumor neurosis factor-α, interleukin-6 (IL-6), plasminogen activatable inhibitor-1, thrombin-activatable fibrinolysis inhibitor, and high-sensitivity c-reactive protein) and cardiovascular, carbohydrate, and lipid profiles were assessed according to standard techniques. Results: VAT volume was greater in TSCI versus PSCI (p=0.042); however, after covarying for age this significance was lost (p>0.05). IL-6 was significantly elevated in TSCI (p<0.05), while other markers of inflammation generally were elevated, but did not reach statistical significance (p>0.05). Systolic blood pressure and total cholesterol were significantly lower in TSCI (p<0.05), while fasting glucose was significantly lower in PSCI (p<0.05). A number of proinflammatory adipokines and cardiometabolic markers significantly correlated with adipose tissue depots by LOI (p<0.05). Conclusion: The results show that LOI does not influence the distribution of adipose tissue, but does influence proinflammatory adipokines and cardiometabolic profiles following SCI. Further research is needed to evaluate impact of lean body mass on these findings.",
author = "Farkas, {Gary J.} and Gorgey, {Ashraf S.} and Dolbow, {David R.} and Berg, {Arthur S.} and Gater, {David R.}",
year = "2018",
month = "7",
day = "4",
doi = "10.1080/10790268.2017.1357918",
language = "English (US)",
volume = "41",
pages = "407--415",
journal = "Journal of Spinal Cord Medicine",
issn = "1079-0268",
publisher = "Maney Publishing",
number = "4",

}

The influence of level of spinal cord injury on adipose tissue and its relationship to inflammatory adipokines and cardiometabolic profiles. / Farkas, Gary J.; Gorgey, Ashraf S.; Dolbow, David R.; Berg, Arthur S.; Gater, David R.

In: Journal of Spinal Cord Medicine, Vol. 41, No. 4, 04.07.2018, p. 407-415.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The influence of level of spinal cord injury on adipose tissue and its relationship to inflammatory adipokines and cardiometabolic profiles

AU - Farkas, Gary J.

AU - Gorgey, Ashraf S.

AU - Dolbow, David R.

AU - Berg, Arthur S.

AU - Gater, David R.

PY - 2018/7/4

Y1 - 2018/7/4

N2 - Objective: Level of injury (LOI) and the role of adipose tissue and its proinflammatory adipokines in cardiometabolic dysfunction following spinal cord injury (SCI) remains poorly understood. We aim to examine the influence of LOI on adipose tissue and its relationship to proinflammatory adipokines and cardiometabolic profiles following SCI. Design: Cross sectional and correlational study. Setting: Clinical hospital and academic setting. Participants: Forty-seven individuals with chronic motor complete SCI (age 43.8±11.5 y, BMI: 27.3±5.3) were classified as having tetraplegia (TSCI; n=12) or paraplegia (PSCI; n=35). Intervention: Non applicable. Outcome Measures: Visceral (VAT) and subcutaneous (SAT) adipose tissue volumes were measured using magnetic resonance imaging. Proinflammatory adipokines (tumor neurosis factor-α, interleukin-6 (IL-6), plasminogen activatable inhibitor-1, thrombin-activatable fibrinolysis inhibitor, and high-sensitivity c-reactive protein) and cardiovascular, carbohydrate, and lipid profiles were assessed according to standard techniques. Results: VAT volume was greater in TSCI versus PSCI (p=0.042); however, after covarying for age this significance was lost (p>0.05). IL-6 was significantly elevated in TSCI (p<0.05), while other markers of inflammation generally were elevated, but did not reach statistical significance (p>0.05). Systolic blood pressure and total cholesterol were significantly lower in TSCI (p<0.05), while fasting glucose was significantly lower in PSCI (p<0.05). A number of proinflammatory adipokines and cardiometabolic markers significantly correlated with adipose tissue depots by LOI (p<0.05). Conclusion: The results show that LOI does not influence the distribution of adipose tissue, but does influence proinflammatory adipokines and cardiometabolic profiles following SCI. Further research is needed to evaluate impact of lean body mass on these findings.

AB - Objective: Level of injury (LOI) and the role of adipose tissue and its proinflammatory adipokines in cardiometabolic dysfunction following spinal cord injury (SCI) remains poorly understood. We aim to examine the influence of LOI on adipose tissue and its relationship to proinflammatory adipokines and cardiometabolic profiles following SCI. Design: Cross sectional and correlational study. Setting: Clinical hospital and academic setting. Participants: Forty-seven individuals with chronic motor complete SCI (age 43.8±11.5 y, BMI: 27.3±5.3) were classified as having tetraplegia (TSCI; n=12) or paraplegia (PSCI; n=35). Intervention: Non applicable. Outcome Measures: Visceral (VAT) and subcutaneous (SAT) adipose tissue volumes were measured using magnetic resonance imaging. Proinflammatory adipokines (tumor neurosis factor-α, interleukin-6 (IL-6), plasminogen activatable inhibitor-1, thrombin-activatable fibrinolysis inhibitor, and high-sensitivity c-reactive protein) and cardiovascular, carbohydrate, and lipid profiles were assessed according to standard techniques. Results: VAT volume was greater in TSCI versus PSCI (p=0.042); however, after covarying for age this significance was lost (p>0.05). IL-6 was significantly elevated in TSCI (p<0.05), while other markers of inflammation generally were elevated, but did not reach statistical significance (p>0.05). Systolic blood pressure and total cholesterol were significantly lower in TSCI (p<0.05), while fasting glucose was significantly lower in PSCI (p<0.05). A number of proinflammatory adipokines and cardiometabolic markers significantly correlated with adipose tissue depots by LOI (p<0.05). Conclusion: The results show that LOI does not influence the distribution of adipose tissue, but does influence proinflammatory adipokines and cardiometabolic profiles following SCI. Further research is needed to evaluate impact of lean body mass on these findings.

UR - http://www.scopus.com/inward/record.url?scp=85048991248&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85048991248&partnerID=8YFLogxK

U2 - 10.1080/10790268.2017.1357918

DO - 10.1080/10790268.2017.1357918

M3 - Article

C2 - 28758566

AN - SCOPUS:85048991248

VL - 41

SP - 407

EP - 415

JO - Journal of Spinal Cord Medicine

JF - Journal of Spinal Cord Medicine

SN - 1079-0268

IS - 4

ER -