The influence of neuropathology on the fMRI Signal: A measurement of brain or vein?

Research output: Contribution to journalReview article

23 Citations (Scopus)

Abstract

There is a rapidly growing literature using fMRI technology to investigate the various forms of behavioral impairment associated with brain injury and disease. Given this, surprisingly little work has been conducted to examine the influence of neuropathophysiological processes on the fMRI signal. This paper reviews the literature examining baseline alteration in cerebrovascular parameters associated with normal aging, brain injury, and brain disease. In addition, findings from three cases of individuals with severe brain trauma will be presented to show the influence of brain trauma on baseline cerebrovascular parameters measured by fMRI. The methods used here can be implemented by other investigators to accurately isolate specific hemodynamic changes that can influence the BOLD fMRI signal.

Original languageEnglish (US)
Pages (from-to)58-72
Number of pages15
JournalClinical Neuropsychologist
Volume21
Issue number1
DOIs
StatePublished - Jan 1 2007

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Veins
Magnetic Resonance Imaging
Brain
Brain Diseases
Brain Injuries
Hemodynamics
Research Personnel
Technology
Neuropathology
Functional Magnetic Resonance Imaging
Traumatic Brain Injury
Brain Injury
Trauma

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health

Cite this

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The influence of neuropathology on the fMRI Signal : A measurement of brain or vein? / Hillary, Frank Gerard; Biswal, B.

In: Clinical Neuropsychologist, Vol. 21, No. 1, 01.01.2007, p. 58-72.

Research output: Contribution to journalReview article

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