The influence of obesity on calf blood flow and vascular reactivity in older adults

Luke S. Acree, Philip C. Comp, Thomas L. Whitsett, Polly S. Montgomery, Kevin J. Nickel, Anette S. Fjeldstad, Cecilie Fjeldstad, Andrew Gardner

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Objective. To determine whether differences in vascular reactivity existed among normal weight, overweight, and obese older men and women, and to examine the association between abdominal fat distribution and vascular reactivity. Methods. Eighty-seven individuals who were 60 years of age or older (age = 69 ± 7 yrs; mean ± SD) were grouped into normal weight (BMI < 25; n = 30), overweight (BMI ≥ 25 and < 30; n = 28), or obese (BMI ≥ 30; n = 29) categories. Calf blood flow (BF) was assessed by venous occlusion strain-gauge plethysmography at rest and post-occlusive reactive hyperemia. Results. Post-occlusive reactive hyperemia BF was lower (p = 0.038) in the obese group (5.55 ± 4.67 %/min) than in the normal weight group (8.34 ± 3.89 %/min). Additionally, change in BF from rest to post-occlusion in the obese group (1.93 ± 2.58 %/min) was lower (p = 0.001) than in the normal weight group (5.21 ± 3.59 %/min), as well as the percentage change (75 ± 98 % vs. 202 ± 190 %, p = 0.006, respectively). After adjusting for age, prevalence in hypertension and calf skinfold thickness, change in BF values remained lower (p < 0.05) in obese subjects compared to the normal weight subjects. Lastly, the absolute and percentage change in BF were significantly related to BMI (r = -0.44, p < 0.001, and r = -0.37, p < 0.001, respectively) and to waist circumference (r = -0.36, p = 0.001, and r = -0.32, p = 0.002). Conclusion. Obesity and abdominal adiposity impair vascular reactivity in older men and women, and these deleterious effects on vascular reactivity are independent of conventional risk factors.

Original languageEnglish (US)
Article number4
JournalDynamic Medicine
Volume6
DOIs
StatePublished - Apr 23 2007

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Blood Vessels
Obesity
Weights and Measures
Hyperemia
Skinfold Thickness
Abdominal Fat
Plethysmography
Abdominal Obesity
Adiposity
Waist Circumference
Hypertension

All Science Journal Classification (ASJC) codes

  • Physiology
  • Orthopedics and Sports Medicine

Cite this

Acree, L. S., Comp, P. C., Whitsett, T. L., Montgomery, P. S., Nickel, K. J., Fjeldstad, A. S., ... Gardner, A. (2007). The influence of obesity on calf blood flow and vascular reactivity in older adults. Dynamic Medicine, 6, [4]. https://doi.org/10.1186/1476-5918-6-4
Acree, Luke S. ; Comp, Philip C. ; Whitsett, Thomas L. ; Montgomery, Polly S. ; Nickel, Kevin J. ; Fjeldstad, Anette S. ; Fjeldstad, Cecilie ; Gardner, Andrew. / The influence of obesity on calf blood flow and vascular reactivity in older adults. In: Dynamic Medicine. 2007 ; Vol. 6.
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abstract = "Objective. To determine whether differences in vascular reactivity existed among normal weight, overweight, and obese older men and women, and to examine the association between abdominal fat distribution and vascular reactivity. Methods. Eighty-seven individuals who were 60 years of age or older (age = 69 ± 7 yrs; mean ± SD) were grouped into normal weight (BMI < 25; n = 30), overweight (BMI ≥ 25 and < 30; n = 28), or obese (BMI ≥ 30; n = 29) categories. Calf blood flow (BF) was assessed by venous occlusion strain-gauge plethysmography at rest and post-occlusive reactive hyperemia. Results. Post-occlusive reactive hyperemia BF was lower (p = 0.038) in the obese group (5.55 ± 4.67 {\%}/min) than in the normal weight group (8.34 ± 3.89 {\%}/min). Additionally, change in BF from rest to post-occlusion in the obese group (1.93 ± 2.58 {\%}/min) was lower (p = 0.001) than in the normal weight group (5.21 ± 3.59 {\%}/min), as well as the percentage change (75 ± 98 {\%} vs. 202 ± 190 {\%}, p = 0.006, respectively). After adjusting for age, prevalence in hypertension and calf skinfold thickness, change in BF values remained lower (p < 0.05) in obese subjects compared to the normal weight subjects. Lastly, the absolute and percentage change in BF were significantly related to BMI (r = -0.44, p < 0.001, and r = -0.37, p < 0.001, respectively) and to waist circumference (r = -0.36, p = 0.001, and r = -0.32, p = 0.002). Conclusion. Obesity and abdominal adiposity impair vascular reactivity in older men and women, and these deleterious effects on vascular reactivity are independent of conventional risk factors.",
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Acree, LS, Comp, PC, Whitsett, TL, Montgomery, PS, Nickel, KJ, Fjeldstad, AS, Fjeldstad, C & Gardner, A 2007, 'The influence of obesity on calf blood flow and vascular reactivity in older adults', Dynamic Medicine, vol. 6, 4. https://doi.org/10.1186/1476-5918-6-4

The influence of obesity on calf blood flow and vascular reactivity in older adults. / Acree, Luke S.; Comp, Philip C.; Whitsett, Thomas L.; Montgomery, Polly S.; Nickel, Kevin J.; Fjeldstad, Anette S.; Fjeldstad, Cecilie; Gardner, Andrew.

In: Dynamic Medicine, Vol. 6, 4, 23.04.2007.

Research output: Contribution to journalArticle

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T1 - The influence of obesity on calf blood flow and vascular reactivity in older adults

AU - Acree, Luke S.

AU - Comp, Philip C.

AU - Whitsett, Thomas L.

AU - Montgomery, Polly S.

AU - Nickel, Kevin J.

AU - Fjeldstad, Anette S.

AU - Fjeldstad, Cecilie

AU - Gardner, Andrew

PY - 2007/4/23

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N2 - Objective. To determine whether differences in vascular reactivity existed among normal weight, overweight, and obese older men and women, and to examine the association between abdominal fat distribution and vascular reactivity. Methods. Eighty-seven individuals who were 60 years of age or older (age = 69 ± 7 yrs; mean ± SD) were grouped into normal weight (BMI < 25; n = 30), overweight (BMI ≥ 25 and < 30; n = 28), or obese (BMI ≥ 30; n = 29) categories. Calf blood flow (BF) was assessed by venous occlusion strain-gauge plethysmography at rest and post-occlusive reactive hyperemia. Results. Post-occlusive reactive hyperemia BF was lower (p = 0.038) in the obese group (5.55 ± 4.67 %/min) than in the normal weight group (8.34 ± 3.89 %/min). Additionally, change in BF from rest to post-occlusion in the obese group (1.93 ± 2.58 %/min) was lower (p = 0.001) than in the normal weight group (5.21 ± 3.59 %/min), as well as the percentage change (75 ± 98 % vs. 202 ± 190 %, p = 0.006, respectively). After adjusting for age, prevalence in hypertension and calf skinfold thickness, change in BF values remained lower (p < 0.05) in obese subjects compared to the normal weight subjects. Lastly, the absolute and percentage change in BF were significantly related to BMI (r = -0.44, p < 0.001, and r = -0.37, p < 0.001, respectively) and to waist circumference (r = -0.36, p = 0.001, and r = -0.32, p = 0.002). Conclusion. Obesity and abdominal adiposity impair vascular reactivity in older men and women, and these deleterious effects on vascular reactivity are independent of conventional risk factors.

AB - Objective. To determine whether differences in vascular reactivity existed among normal weight, overweight, and obese older men and women, and to examine the association between abdominal fat distribution and vascular reactivity. Methods. Eighty-seven individuals who were 60 years of age or older (age = 69 ± 7 yrs; mean ± SD) were grouped into normal weight (BMI < 25; n = 30), overweight (BMI ≥ 25 and < 30; n = 28), or obese (BMI ≥ 30; n = 29) categories. Calf blood flow (BF) was assessed by venous occlusion strain-gauge plethysmography at rest and post-occlusive reactive hyperemia. Results. Post-occlusive reactive hyperemia BF was lower (p = 0.038) in the obese group (5.55 ± 4.67 %/min) than in the normal weight group (8.34 ± 3.89 %/min). Additionally, change in BF from rest to post-occlusion in the obese group (1.93 ± 2.58 %/min) was lower (p = 0.001) than in the normal weight group (5.21 ± 3.59 %/min), as well as the percentage change (75 ± 98 % vs. 202 ± 190 %, p = 0.006, respectively). After adjusting for age, prevalence in hypertension and calf skinfold thickness, change in BF values remained lower (p < 0.05) in obese subjects compared to the normal weight subjects. Lastly, the absolute and percentage change in BF were significantly related to BMI (r = -0.44, p < 0.001, and r = -0.37, p < 0.001, respectively) and to waist circumference (r = -0.36, p = 0.001, and r = -0.32, p = 0.002). Conclusion. Obesity and abdominal adiposity impair vascular reactivity in older men and women, and these deleterious effects on vascular reactivity are independent of conventional risk factors.

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Acree LS, Comp PC, Whitsett TL, Montgomery PS, Nickel KJ, Fjeldstad AS et al. The influence of obesity on calf blood flow and vascular reactivity in older adults. Dynamic Medicine. 2007 Apr 23;6. 4. https://doi.org/10.1186/1476-5918-6-4