The interaction of Cl- with a gramicidin-like channel

Shen Shu Sung, Peter C. Jordan

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Molecular dynamics simulations have been used to study the interaction of Cl- with a gramicidin-like channel. The results suggest that there is a high-energy barrier at the entrance of the channel, which would correspond to a permeability 10-9-times that of a cation of the same size. This could account for the cationic selectivity of the gramicidin channel and indicates that valence selectivity is kinetically controlled.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalBiophysical Chemistry
Volume27
Issue number1
DOIs
StatePublished - Jul 1987

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Organic Chemistry

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