The interaction of Cl- with a gramicidin-like channel

Shen-shu Sung, Peter C. Jordan

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Molecular dynamics simulations have been used to study the interaction of Cl- with a gramicidin-like channel. The results suggest that there is a high-energy barrier at the entrance of the channel, which would correspond to a permeability 10-9-times that of a cation of the same size. This could account for the cationic selectivity of the gramicidin channel and indicates that valence selectivity is kinetically controlled.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalBiophysical Chemistry
Volume27
Issue number1
DOIs
StatePublished - Jan 1 1987

Fingerprint

Gramicidin
Energy barriers
Molecular Dynamics Simulation
Molecular dynamics
Cations
Permeability
Computer simulation

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Organic Chemistry

Cite this

Sung, Shen-shu ; Jordan, Peter C. / The interaction of Cl- with a gramicidin-like channel. In: Biophysical Chemistry. 1987 ; Vol. 27, No. 1. pp. 1-6.
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The interaction of Cl- with a gramicidin-like channel. / Sung, Shen-shu; Jordan, Peter C.

In: Biophysical Chemistry, Vol. 27, No. 1, 01.01.1987, p. 1-6.

Research output: Contribution to journalArticle

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