The interface of the immune and reproductive systems in the ovary: Lessons learned from the corpus luteum of domestic animal models

Joy Lee Pate, Koji Toyokawa, Sadhat Walusimbi, Edyta Brzezicka

Research output: Contribution to journalReview article

42 Citations (Scopus)

Abstract

The dynamic changes that characterize the female reproductive system are regulated by hormones. However, local cell-to-cell interactions may mediate responsiveness of tissues to hormonal signals. The corpus luteum (CL) is an excellent model for understanding how immune cells are recruited into tissues and the role played by those cells in regulating tissue homeostasis or demise. Leukocytes are recruited into the CL throughout its lifespan, and leukocyte-derived cytokines have been found in corpora lutea of all species examined. The proinflammatory cytokines inhibit gonadotropin-stimulated steroidogenesis, profoundly stimulate prostaglandin synthesis by luteal cells, and promote apoptosis. However, there is mounting evidence that leukocytes and luteal cells communicate in different ways to maintain homeostasis within the functional CL. Domestic animals have provided important information regarding the presence and role of immune cells in the CL.

Original languageEnglish (US)
Pages (from-to)275-286
Number of pages12
JournalAmerican Journal of Reproductive Immunology
Volume64
Issue number4
DOIs
StatePublished - Oct 1 2010

Fingerprint

Corpus Luteum
Domestic Animals
Ovary
Immune System
Animal Models
Luteal Cells
Leukocytes
Homeostasis
Cytokines
Gonadotropins
Cell Communication
Prostaglandins
Hormones
Apoptosis

All Science Journal Classification (ASJC) codes

  • Immunology
  • Immunology and Allergy
  • Obstetrics and Gynecology
  • Reproductive Medicine

Cite this

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abstract = "The dynamic changes that characterize the female reproductive system are regulated by hormones. However, local cell-to-cell interactions may mediate responsiveness of tissues to hormonal signals. The corpus luteum (CL) is an excellent model for understanding how immune cells are recruited into tissues and the role played by those cells in regulating tissue homeostasis or demise. Leukocytes are recruited into the CL throughout its lifespan, and leukocyte-derived cytokines have been found in corpora lutea of all species examined. The proinflammatory cytokines inhibit gonadotropin-stimulated steroidogenesis, profoundly stimulate prostaglandin synthesis by luteal cells, and promote apoptosis. However, there is mounting evidence that leukocytes and luteal cells communicate in different ways to maintain homeostasis within the functional CL. Domestic animals have provided important information regarding the presence and role of immune cells in the CL.",
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The interface of the immune and reproductive systems in the ovary : Lessons learned from the corpus luteum of domestic animal models. / Pate, Joy Lee; Toyokawa, Koji; Walusimbi, Sadhat; Brzezicka, Edyta.

In: American Journal of Reproductive Immunology, Vol. 64, No. 4, 01.10.2010, p. 275-286.

Research output: Contribution to journalReview article

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