The interference of monoclonal antibodies with laboratory diagnosis: Clinical and diagnostic implications

Barbara E. Ostrov, Daniel Amsterdam

Research output: Contribution to journalReview article

6 Scopus citations

Abstract

Diagnostic test interference is due to the presence of material that falsely changes an analytic test result. The development of monoclonal antibodies is discussed with focus on their extensive use as both therapeutic and diagnostic agents. In this review the interference of monoclonal antibodies with laboratory test methods and the potential impact on clinical care is addressed. Recognition of the types of interference, endogenous and exogenous, and the varied mechanisms by which monoclonal antibodies may cause interference are discussed in this report. Review of the literature identifies cases which exemplify the issues facing laboratorians and clinicians and describe the impact on patients. Approaches to reducing and eliminating sources of interference are also addressed. Education of ordering clinicians concerning the possibility of interference in at-risk patients is key in limiting the impact on care. Laboratorians and medical practitioners should be cognizant of the risk of interference to avoid incorrect management of patients.

Original languageEnglish (US)
Pages (from-to)673-690
Number of pages18
JournalImmunological Investigations
Volume42
Issue number8
DOIs
StatePublished - Oct 18 2013

All Science Journal Classification (ASJC) codes

  • Immunology

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