The intestinal metabolome: An intersection between microbiota and host

Luke K. Ursell, Henry J. Haiser, Will Van Treuren, Neha Garg, Lavanya Reddivari, Jairam K.P. Vanamala, Pieter C. Dorrestein, Peter J. Turnbaugh, Rob Knight

Research output: Contribution to journalArticle

96 Citations (Scopus)

Abstract

Recent advances that allow us to collect more data on DNA sequences and metabolites have increased our understanding of connections between the intestinal microbiota and metabolites at a whole-systems level. We can also now better study the effects of specific microbes on specific metabolites. Here, we review how the microbiota determines levels of specific metabolites, how the metabolite profile develops in infants, and prospects for assessing a person's physiological state based on their microbes and/or metabolites. Although data acquisition technologies have improved, the computational challenges in integrating data from multiple levels remain formidable; developments in this area will significantly improve our ability to interpret current and future data sets.

Original languageEnglish (US)
Pages (from-to)1470-1476
Number of pages7
JournalGastroenterology
Volume146
Issue number6
DOIs
StatePublished - Jan 1 2014

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Metabolome
Microbiota
Technology
Gastrointestinal Microbiome
Datasets

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

Ursell, L. K., Haiser, H. J., Van Treuren, W., Garg, N., Reddivari, L., Vanamala, J. K. P., ... Knight, R. (2014). The intestinal metabolome: An intersection between microbiota and host. Gastroenterology, 146(6), 1470-1476. https://doi.org/10.1053/j.gastro.2014.03.001
Ursell, Luke K. ; Haiser, Henry J. ; Van Treuren, Will ; Garg, Neha ; Reddivari, Lavanya ; Vanamala, Jairam K.P. ; Dorrestein, Pieter C. ; Turnbaugh, Peter J. ; Knight, Rob. / The intestinal metabolome : An intersection between microbiota and host. In: Gastroenterology. 2014 ; Vol. 146, No. 6. pp. 1470-1476.
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Ursell, LK, Haiser, HJ, Van Treuren, W, Garg, N, Reddivari, L, Vanamala, JKP, Dorrestein, PC, Turnbaugh, PJ & Knight, R 2014, 'The intestinal metabolome: An intersection between microbiota and host', Gastroenterology, vol. 146, no. 6, pp. 1470-1476. https://doi.org/10.1053/j.gastro.2014.03.001

The intestinal metabolome : An intersection between microbiota and host. / Ursell, Luke K.; Haiser, Henry J.; Van Treuren, Will; Garg, Neha; Reddivari, Lavanya; Vanamala, Jairam K.P.; Dorrestein, Pieter C.; Turnbaugh, Peter J.; Knight, Rob.

In: Gastroenterology, Vol. 146, No. 6, 01.01.2014, p. 1470-1476.

Research output: Contribution to journalArticle

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Ursell LK, Haiser HJ, Van Treuren W, Garg N, Reddivari L, Vanamala JKP et al. The intestinal metabolome: An intersection between microbiota and host. Gastroenterology. 2014 Jan 1;146(6):1470-1476. https://doi.org/10.1053/j.gastro.2014.03.001