The intestinal metabolome: An intersection between microbiota and host

Luke K. Ursell, Henry J. Haiser, Will Van Treuren, Neha Garg, Lavanya Reddivari, Jairam Vanamala, Pieter C. Dorrestein, Peter J. Turnbaugh, Rob Knight

Research output: Contribution to journalArticle

113 Scopus citations

Abstract

Recent advances that allow us to collect more data on DNA sequences and metabolites have increased our understanding of connections between the intestinal microbiota and metabolites at a whole-systems level. We can also now better study the effects of specific microbes on specific metabolites. Here, we review how the microbiota determines levels of specific metabolites, how the metabolite profile develops in infants, and prospects for assessing a person's physiological state based on their microbes and/or metabolites. Although data acquisition technologies have improved, the computational challenges in integrating data from multiple levels remain formidable; developments in this area will significantly improve our ability to interpret current and future data sets.

Original languageEnglish (US)
Pages (from-to)1470-1476
Number of pages7
JournalGastroenterology
Volume146
Issue number6
DOIs
StatePublished - May 2014

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

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    Ursell, L. K., Haiser, H. J., Van Treuren, W., Garg, N., Reddivari, L., Vanamala, J., Dorrestein, P. C., Turnbaugh, P. J., & Knight, R. (2014). The intestinal metabolome: An intersection between microbiota and host. Gastroenterology, 146(6), 1470-1476. https://doi.org/10.1053/j.gastro.2014.03.001