The Kell blood group protein, its relation to XK and its function as an endothelin-3-converting enzyme

Colvin M. Redman, David C.W. Russo, Jeffrey J. Pu, Soohee Lee

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)

Abstract

Kell is a 93kDa type II membrane glycoprotein that exists in over 25 different polymorphic forms and, because various forms are immunogenic, it is considered to be an important blood group protein. On red cells, Kell protein is linked by a single disulfide bond to another protein, XK that is lacking in the McLeod phenotype. Kell and XK are preferentially expressed in erythroid tissue but are also present, in lesser amount, in a large number of other tissues including testis, brain, and skeletal muscle. Kell protein is an endothelin converting enzyme that preferentially activates endothelin-3 while XK has the structural characteristics of a membrane transporter.

Original languageEnglish (US)
Title of host publicationNeuroacanthocytosis Syndromes
PublisherSpringer Netherlands
Pages197-203
Number of pages7
ISBN (Electronic)9781402028984
ISBN (Print)1402028970, 9781402028977
DOIs
StatePublished - Jan 1 2005

Fingerprint

Endothelin-3
Blood Group Antigens
Blood Proteins
Proteins
Membrane Transport Proteins
Membrane Glycoproteins
Disulfides
Testis
Skeletal Muscle
Phenotype
Brain
Endothelin-Converting Enzymes

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Neuroscience(all)

Cite this

Redman, C. M., Russo, D. C. W., Pu, J. J., & Lee, S. (2005). The Kell blood group protein, its relation to XK and its function as an endothelin-3-converting enzyme. In Neuroacanthocytosis Syndromes (pp. 197-203). Springer Netherlands. https://doi.org/10.1007/1-4020-2898-9_22
Redman, Colvin M. ; Russo, David C.W. ; Pu, Jeffrey J. ; Lee, Soohee. / The Kell blood group protein, its relation to XK and its function as an endothelin-3-converting enzyme. Neuroacanthocytosis Syndromes. Springer Netherlands, 2005. pp. 197-203
@inbook{2fab30b0b239485ba0299f64c7e453c2,
title = "The Kell blood group protein, its relation to XK and its function as an endothelin-3-converting enzyme",
abstract = "Kell is a 93kDa type II membrane glycoprotein that exists in over 25 different polymorphic forms and, because various forms are immunogenic, it is considered to be an important blood group protein. On red cells, Kell protein is linked by a single disulfide bond to another protein, XK that is lacking in the McLeod phenotype. Kell and XK are preferentially expressed in erythroid tissue but are also present, in lesser amount, in a large number of other tissues including testis, brain, and skeletal muscle. Kell protein is an endothelin converting enzyme that preferentially activates endothelin-3 while XK has the structural characteristics of a membrane transporter.",
author = "Redman, {Colvin M.} and Russo, {David C.W.} and Pu, {Jeffrey J.} and Soohee Lee",
year = "2005",
month = "1",
day = "1",
doi = "10.1007/1-4020-2898-9_22",
language = "English (US)",
isbn = "1402028970",
pages = "197--203",
booktitle = "Neuroacanthocytosis Syndromes",
publisher = "Springer Netherlands",
address = "Netherlands",

}

Redman, CM, Russo, DCW, Pu, JJ & Lee, S 2005, The Kell blood group protein, its relation to XK and its function as an endothelin-3-converting enzyme. in Neuroacanthocytosis Syndromes. Springer Netherlands, pp. 197-203. https://doi.org/10.1007/1-4020-2898-9_22

The Kell blood group protein, its relation to XK and its function as an endothelin-3-converting enzyme. / Redman, Colvin M.; Russo, David C.W.; Pu, Jeffrey J.; Lee, Soohee.

Neuroacanthocytosis Syndromes. Springer Netherlands, 2005. p. 197-203.

Research output: Chapter in Book/Report/Conference proceedingChapter

TY - CHAP

T1 - The Kell blood group protein, its relation to XK and its function as an endothelin-3-converting enzyme

AU - Redman, Colvin M.

AU - Russo, David C.W.

AU - Pu, Jeffrey J.

AU - Lee, Soohee

PY - 2005/1/1

Y1 - 2005/1/1

N2 - Kell is a 93kDa type II membrane glycoprotein that exists in over 25 different polymorphic forms and, because various forms are immunogenic, it is considered to be an important blood group protein. On red cells, Kell protein is linked by a single disulfide bond to another protein, XK that is lacking in the McLeod phenotype. Kell and XK are preferentially expressed in erythroid tissue but are also present, in lesser amount, in a large number of other tissues including testis, brain, and skeletal muscle. Kell protein is an endothelin converting enzyme that preferentially activates endothelin-3 while XK has the structural characteristics of a membrane transporter.

AB - Kell is a 93kDa type II membrane glycoprotein that exists in over 25 different polymorphic forms and, because various forms are immunogenic, it is considered to be an important blood group protein. On red cells, Kell protein is linked by a single disulfide bond to another protein, XK that is lacking in the McLeod phenotype. Kell and XK are preferentially expressed in erythroid tissue but are also present, in lesser amount, in a large number of other tissues including testis, brain, and skeletal muscle. Kell protein is an endothelin converting enzyme that preferentially activates endothelin-3 while XK has the structural characteristics of a membrane transporter.

UR - http://www.scopus.com/inward/record.url?scp=33644851872&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33644851872&partnerID=8YFLogxK

U2 - 10.1007/1-4020-2898-9_22

DO - 10.1007/1-4020-2898-9_22

M3 - Chapter

AN - SCOPUS:33644851872

SN - 1402028970

SN - 9781402028977

SP - 197

EP - 203

BT - Neuroacanthocytosis Syndromes

PB - Springer Netherlands

ER -

Redman CM, Russo DCW, Pu JJ, Lee S. The Kell blood group protein, its relation to XK and its function as an endothelin-3-converting enzyme. In Neuroacanthocytosis Syndromes. Springer Netherlands. 2005. p. 197-203 https://doi.org/10.1007/1-4020-2898-9_22