The Kell blood group protein, its relation to XK and its function as an endothelin-3-converting enzyme

Colvin M. Redman, David C.W. Russo, Jeffrey J. Pu, Soohee Lee

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Abstract

Kell is a 93kDa type II membrane glycoprotein that exists in over 25 different polymorphic forms and, because various forms are immunogenic, it is considered to be an important blood group protein. On red cells, Kell protein is linked by a single disulfide bond to another protein, XK that is lacking in the McLeod phenotype. Kell and XK are preferentially expressed in erythroid tissue but are also present, in lesser amount, in a large number of other tissues including testis, brain, and skeletal muscle. Kell protein is an endothelin converting enzyme that preferentially activates endothelin-3 while XK has the structural characteristics of a membrane transporter.

Original languageEnglish (US)
Title of host publicationNeuroacanthocytosis Syndromes
PublisherSpringer Netherlands
Pages197-203
Number of pages7
ISBN (Electronic)9781402028984
ISBN (Print)1402028970, 9781402028977
DOIs
StatePublished - Jan 1 2005

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Neuroscience(all)

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