The long-term effects of the neurotoxin l-trichloromethyl-1,2,3,4- tetrahydro-β-carboline (TaClo) on cognitive performance in rats

T. A. Sontag, K. W. Lange, Ch Heim, W. Kolasiewicz, O. Tucha, K. H. Sontag

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Abstract

The neurotoxin l-trichloromethyl-l,2,3,4-tetrahydro-β-carboline (TaClo) has been reported, both in vitro and in vivo models, to produce neurodegeneration and parkinsonian symptoms after prolonged exposure in rats. The aim of the present study was to investigate the effects of TaClo on the cognitive performance of rats. We used the COGITAT hole board system where rats can find hidden pellets by exploring the board. TaClo-treated rats found as many pellets as control rats treated with saline. Furthermore, their search was as efficient as that of control animals since there were no differences between the groups regarding explorative activity, visits to nonbaited holes and time needed to find the pellets. These results suggest that there is no deficit in spatial memory following the chronic administration of TaClo to rats.

Original languageEnglish (US)
Title of host publicationNeuropsychiatric Disorders An Integrative Approach
EditorsManfred Gerlach, Jurgen Deckert, Kay Double, Eleni Koutsilieri
Pages149-154
Number of pages6
Edition72
DOIs
StatePublished - Dec 1 2007

Publication series

NameJournal of Neural Transmission, Supplementa
Number72
ISSN (Print)0303-6995

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry

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    Sontag, T. A., Lange, K. W., Heim, C., Kolasiewicz, W., Tucha, O., & Sontag, K. H. (2007). The long-term effects of the neurotoxin l-trichloromethyl-1,2,3,4- tetrahydro-β-carboline (TaClo) on cognitive performance in rats. In M. Gerlach, J. Deckert, K. Double, & E. Koutsilieri (Eds.), Neuropsychiatric Disorders An Integrative Approach (72 ed., pp. 149-154). (Journal of Neural Transmission, Supplementa; No. 72). https://doi.org/10.1007/978-3-211-73574-9-18