The major histocompatibility complex and human evolution

Jan Klein, Jutta Gutknecht, Norbert Fischer

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Many alleles at the human major histocompatibility complex (HLA) loci diverged before the divergence of humans and great apes from a common ancestor. This fact puts a lower limit on the size of the bottleneck in human evolution: the genus Homo must have been founded by no less than ten and probably by more than 10 000 individuals.

Original languageEnglish (US)
Pages (from-to)7-11
Number of pages5
JournalTrends in Genetics
Volume6
Issue numberC
DOIs
StatePublished - Jan 1 1990

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Major Histocompatibility Complex
Hominidae
Alleles

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

Klein, Jan ; Gutknecht, Jutta ; Fischer, Norbert. / The major histocompatibility complex and human evolution. In: Trends in Genetics. 1990 ; Vol. 6, No. C. pp. 7-11.
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The major histocompatibility complex and human evolution. / Klein, Jan; Gutknecht, Jutta; Fischer, Norbert.

In: Trends in Genetics, Vol. 6, No. C, 01.01.1990, p. 7-11.

Research output: Contribution to journalArticle

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