The major histocompatibility complex-related Fc receptor for IgG (FcRn) binds albumin and prolongs its lifespan

Chaity Chaudhury, Samina Mehnaz, John M. Robinson, William L. Hayton, Dennis K. Pearl, Derry C. Roopenian, Clark L. Anderson

Research output: Contribution to journalArticlepeer-review

373 Scopus citations

Abstract

The inverse relationship between serum albumin concentration and its half-life suggested to early workers that albumin would be protected from a catabolic fate by a receptor-mediated mechanism much like that proposed for IgG. We show here that albumin binds FcRn in a pH dependent fashion, that the lifespan of albumin is shortened in FcRn-deficient mice, and that the plasma albumin concentration of FcRn-deficient mice is less than half that of wild-type mice. These results affirm the hypothesis that the major histocompatibility complex-related Fc receptor protects albumin from degradation just as it does IgG, prolonging the half-lives of both.

Original languageEnglish (US)
Pages (from-to)315-322
Number of pages8
JournalJournal of Experimental Medicine
Volume197
Issue number3
DOIs
StatePublished - Feb 3 2003

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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