TY - JOUR
T1 - The mammalian TRPC cation channels
AU - Vazquez, Guillermo
AU - Wedel, Barbara J.
AU - Aziz, Omar
AU - Trebak, Mohamed
AU - Putney, James W.
PY - 2004/12/6
Y1 - 2004/12/6
N2 - Transient Receptor Potential-Canonical (TRPC) channels are mammalian homologs of Transient Receptor Potential (TRP), a Ca 2+-permeable channel involved in the phospholipase C-regulated photoreceptor activation mechanism in Drosophila. The seven mammalian TRPCs constitute a family of channels which have been proposed to function as store-operated as well as second messenger-operated channels in a variety of cell types. TRPC channels, together with other more distantly related channel families, make up the larger TRP channel superfamily. This review summarizes recent findings on the structure, regulation and function of the apparently ubiquitous TRPC cation channels.
AB - Transient Receptor Potential-Canonical (TRPC) channels are mammalian homologs of Transient Receptor Potential (TRP), a Ca 2+-permeable channel involved in the phospholipase C-regulated photoreceptor activation mechanism in Drosophila. The seven mammalian TRPCs constitute a family of channels which have been proposed to function as store-operated as well as second messenger-operated channels in a variety of cell types. TRPC channels, together with other more distantly related channel families, make up the larger TRP channel superfamily. This review summarizes recent findings on the structure, regulation and function of the apparently ubiquitous TRPC cation channels.
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U2 - 10.1016/j.bbamcr.2004.08.015
DO - 10.1016/j.bbamcr.2004.08.015
M3 - Article
C2 - 15590053
AN - SCOPUS:10044259546
SN - 0167-4889
VL - 1742
SP - 21
EP - 36
JO - Biochimica et Biophysica Acta - Molecular Cell Research
JF - Biochimica et Biophysica Acta - Molecular Cell Research
IS - 1-3
ER -