The many faces of β-TrCP E3 ubiquitin ligases: Reflections in the magic mirror of cancer

Serge Y. Fuchs, Vladimir S. Spiegelman, K. G.Suresh Kumar

Research output: Contribution to journalReview article

224 Scopus citations

Abstract

Beta-transducin repeats-containing proteins (β-TrCP) serve as the substrate recognition subunits for the SCFβ-TrCP E3 ubiquitin ligases. These ligases ubiquitinate specifically phosphorylated substrates and play a pivotal role in the regulation of cell division and various signal transduction pathways, which, in turn, are essential for many aspects of tumorigenesis. We review the functions of the SCFβ-TrCP ligases in the light of their relevance to cell growth, survival and transformation. Mechanisms underlying β-TrCP regulation and their aberration in human and animal cancer as well as prospective of targeting β-TrCP as a means of anticancer therapy are also discussed.

Original languageEnglish (US)
Pages (from-to)2028-2036
Number of pages9
JournalOncogene
Volume23
Issue number11 REV. ISS. 1
DOIs
StatePublished - Mar 15 2004

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All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Cancer Research

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