The minimal length of the differential segment in H-2 congenic lines

Dagmar Klein, Sneh Tewarson, Felipe Figueroa, Jan Klein

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

One hundred and four H-2 congenic lines were typed for alleles at seven loci, Qa-1, Qa-2, Tla, C3, Ce-2, Pgk-2, and Upg-1, residing distal to the H-2 complex. The results of the typing were used to estimate the length of the segment of chromosome 17 derived from the donor strain of each line-that is, the minimal length of the differential segment. The results indicate that only lines derived by intra-H-2 crossing-over in such a way that they inherited the right-hand portion of H-2 from the inbred partner have the telomeric half of chromosome 17 identical with that of the inbred-partner strain. In other lines the differential segment is at least 3 to 10 cM long. It is argued that in some lines the entire telomeric half of chromosome 17 might be of donor-strain origin.

Original languageEnglish (US)
Pages (from-to)319-328
Number of pages10
JournalImmunogenetics
Volume16
Issue number4
DOIs
StatePublished - Oct 1982

All Science Journal Classification (ASJC) codes

  • Immunology
  • Genetics

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