The modulating effect of an inhibitor of cholesterolgenesis present in bovine milk upon the synthesis of cholesterol, dolichol and ubiquinone

B. J. Dull, R. D. McCarthy, A. Kilara

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Bovine milk contains two inhibitors of hepatic cholesterolgenesis. One of these, identified as orotic acid, influences the early segment of the cholesterol biosynthetic pathway and suppresses the conversion of acetate to mevalonate. In this study the other inhibitor was shown to curtail the formation of compounds past farnesyl pyrophosphate on the squalene-cholesterol branch of the pathway. Thus cholesterol synthesis may be suppressed while the production of two other products of the branched pathway, dolichol and ubiquinone, is allowed to continue. The possible role of these ingested regulators in the metabolism of the young until they achieve sufficient development is discussed.

Original languageEnglish (US)
Pages (from-to)231-239
Number of pages9
JournalAtherosclerosis
Volume49
Issue number3
DOIs
StatePublished - Dec 1983

Fingerprint

Dolichol
Ubiquinone
Milk
Cholesterol
Orotic Acid
Squalene
Mevalonic Acid
Biosynthetic Pathways
Acetates
Liver

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

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abstract = "Bovine milk contains two inhibitors of hepatic cholesterolgenesis. One of these, identified as orotic acid, influences the early segment of the cholesterol biosynthetic pathway and suppresses the conversion of acetate to mevalonate. In this study the other inhibitor was shown to curtail the formation of compounds past farnesyl pyrophosphate on the squalene-cholesterol branch of the pathway. Thus cholesterol synthesis may be suppressed while the production of two other products of the branched pathway, dolichol and ubiquinone, is allowed to continue. The possible role of these ingested regulators in the metabolism of the young until they achieve sufficient development is discussed.",
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The modulating effect of an inhibitor of cholesterolgenesis present in bovine milk upon the synthesis of cholesterol, dolichol and ubiquinone. / Dull, B. J.; McCarthy, R. D.; Kilara, A.

In: Atherosclerosis, Vol. 49, No. 3, 12.1983, p. 231-239.

Research output: Contribution to journalArticle

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