The Molecular Mechanisms that Promote Edema After Intracerebral Hemorrhage

Daniel Bodmer, Kerry A. Vaughan, Brad E. Zacharia, Zachary L. Hickman, E. Sander Connolly

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations

Abstract

Intracerebral hemorrhage (ICH) is a devastating type of stroke with no effective therapies. Clinical advances in ICH treatment are limited by an incomplete understanding of the molecular mechanisms responsible for secondary injury and poor outcome. Increasing evidence suggests that cerebral edema is a major contributor to secondary injury and poor outcome in ICH. ICH activates specific signaling pathways that promote edema and damage neuronal tissue. By increasing our understanding of these pathways, we may be able to target them pharmaceutically to reduce edema in ICH patients. In this review, we focus on three major signaling pathways that promote edema after ICH: (1) the coagulation cascade and thrombin, (2) the inflammatory response and matrix metalloproteinases, and (3) the complement cascade and hemoglobin toxicity. We will describe the experimental evidence that confirms these pathways promote edema in ICH, discuss potential targets for new therapies, and comment on important directions for future research.

Original languageEnglish (US)
Pages (from-to)52-61
Number of pages10
JournalTranslational Stroke Research
Volume3
Issue numberSUPPL. 1
DOIs
StatePublished - Jul 2012

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

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