The Multiphase Optimization Strategy (MOST) and the Sequential Multiple Assignment Randomized Trial (SMART). New Methods for More Potent eHealth Interventions

Linda M. Collins, Susan A. Murphy, Victor Strecher

Research output: Contribution to journalArticle

355 Citations (Scopus)

Abstract

Abstract: In this article two new methods for building and evaluating eHealth interventions are described. The first is the Multiphase Optimization Strategy (MOST). It consists of a screening phase, in which intervention components are efficiently identified for inclusion in an intervention or for rejection, based on their performance; a refining phase, in which the selected components are fine tuned and issues such as optimal levels of each component are investigated; and a confirming phase, in which the optimized intervention, consisting of the selected components delivered at optimal levels, is evaluated in a standard randomized controlled trial. The second is the Sequential Multiple Assignment Randomized Trial (SMART), which is an innovative research design especially suited for building time-varying adaptive interventions. A SMART trial can be used to identify the best tailoring variables and decision rules for an adaptive intervention empirically. Both the MOST and SMART approaches use randomized experimentation to enable valid inferences. When properly implemented, these approaches will lead to the development of more potent eHealth interventions.

Original languageEnglish (US)
Pages (from-to)S112-S118
JournalAmerican Journal of Preventive Medicine
Volume32
Issue number5 SUPPL.
DOIs
StatePublished - May 1 2007

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Telemedicine
Research Design
Randomized Controlled Trials

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Public Health, Environmental and Occupational Health

Cite this

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The Multiphase Optimization Strategy (MOST) and the Sequential Multiple Assignment Randomized Trial (SMART). New Methods for More Potent eHealth Interventions. / Collins, Linda M.; Murphy, Susan A.; Strecher, Victor.

In: American Journal of Preventive Medicine, Vol. 32, No. 5 SUPPL., 01.05.2007, p. S112-S118.

Research output: Contribution to journalArticle

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