The Myofibroblastic Component of Rubeosis Iridis

Thomas John, Joseph Sassani, Ralph C. Eagle

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Nineteen blind eyes enucleated for painful angle closure-glaucoma secondary to iris neovascularization (rubeosis iridis) were examined by scanning electron microscopy and correlative light and transmission electron microscopy. Fresh and deparaffinized tissue from patients with diabetes mellitus, central retinal vein occlusion, and retinoblastoma were studied. Scanning electron microscopy revealed extensive peripheral anterior synechia formation and flattening and effacement of the anterior iridic surface by a confluent fibrovascular membrane. New vessels on the anterior iris uniformly were hidden beneath a clinically inapparent, superficial layer of myofibroblasts, ie, fibroblastic cells with smooth muscle differentiation. Myofibroblasts may provide the motive force for synechial closure and ectropion iridis in neovascular glaucoma.

Original languageEnglish (US)
Pages (from-to)721-728
Number of pages8
JournalOphthalmology
Volume90
Issue number6
DOIs
StatePublished - Jan 1 1983

Fingerprint

Myofibroblasts
Iris
Electron Scanning Microscopy
Ectropion
Neovascular Glaucoma
Retinal Vein
Angle Closure Glaucoma
Retinal Vein Occlusion
Retinoblastoma
Transmission Electron Microscopy
Smooth Muscle Myocytes
Diabetes Mellitus
Light
Membranes

All Science Journal Classification (ASJC) codes

  • Ophthalmology

Cite this

John, Thomas ; Sassani, Joseph ; Eagle, Ralph C. / The Myofibroblastic Component of Rubeosis Iridis. In: Ophthalmology. 1983 ; Vol. 90, No. 6. pp. 721-728.
@article{169c6f2ba0d54b88b706bc82213093ad,
title = "The Myofibroblastic Component of Rubeosis Iridis",
abstract = "Nineteen blind eyes enucleated for painful angle closure-glaucoma secondary to iris neovascularization (rubeosis iridis) were examined by scanning electron microscopy and correlative light and transmission electron microscopy. Fresh and deparaffinized tissue from patients with diabetes mellitus, central retinal vein occlusion, and retinoblastoma were studied. Scanning electron microscopy revealed extensive peripheral anterior synechia formation and flattening and effacement of the anterior iridic surface by a confluent fibrovascular membrane. New vessels on the anterior iris uniformly were hidden beneath a clinically inapparent, superficial layer of myofibroblasts, ie, fibroblastic cells with smooth muscle differentiation. Myofibroblasts may provide the motive force for synechial closure and ectropion iridis in neovascular glaucoma.",
author = "Thomas John and Joseph Sassani and Eagle, {Ralph C.}",
year = "1983",
month = "1",
day = "1",
doi = "10.1016/S0161-6420(83)34520-6",
language = "English (US)",
volume = "90",
pages = "721--728",
journal = "Ophthalmology",
issn = "0161-6420",
publisher = "Elsevier Inc.",
number = "6",

}

The Myofibroblastic Component of Rubeosis Iridis. / John, Thomas; Sassani, Joseph; Eagle, Ralph C.

In: Ophthalmology, Vol. 90, No. 6, 01.01.1983, p. 721-728.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The Myofibroblastic Component of Rubeosis Iridis

AU - John, Thomas

AU - Sassani, Joseph

AU - Eagle, Ralph C.

PY - 1983/1/1

Y1 - 1983/1/1

N2 - Nineteen blind eyes enucleated for painful angle closure-glaucoma secondary to iris neovascularization (rubeosis iridis) were examined by scanning electron microscopy and correlative light and transmission electron microscopy. Fresh and deparaffinized tissue from patients with diabetes mellitus, central retinal vein occlusion, and retinoblastoma were studied. Scanning electron microscopy revealed extensive peripheral anterior synechia formation and flattening and effacement of the anterior iridic surface by a confluent fibrovascular membrane. New vessels on the anterior iris uniformly were hidden beneath a clinically inapparent, superficial layer of myofibroblasts, ie, fibroblastic cells with smooth muscle differentiation. Myofibroblasts may provide the motive force for synechial closure and ectropion iridis in neovascular glaucoma.

AB - Nineteen blind eyes enucleated for painful angle closure-glaucoma secondary to iris neovascularization (rubeosis iridis) were examined by scanning electron microscopy and correlative light and transmission electron microscopy. Fresh and deparaffinized tissue from patients with diabetes mellitus, central retinal vein occlusion, and retinoblastoma were studied. Scanning electron microscopy revealed extensive peripheral anterior synechia formation and flattening and effacement of the anterior iridic surface by a confluent fibrovascular membrane. New vessels on the anterior iris uniformly were hidden beneath a clinically inapparent, superficial layer of myofibroblasts, ie, fibroblastic cells with smooth muscle differentiation. Myofibroblasts may provide the motive force for synechial closure and ectropion iridis in neovascular glaucoma.

UR - http://www.scopus.com/inward/record.url?scp=0020640789&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020640789&partnerID=8YFLogxK

U2 - 10.1016/S0161-6420(83)34520-6

DO - 10.1016/S0161-6420(83)34520-6

M3 - Article

C2 - 6193475

AN - SCOPUS:0020640789

VL - 90

SP - 721

EP - 728

JO - Ophthalmology

JF - Ophthalmology

SN - 0161-6420

IS - 6

ER -