The natural history of human papillomavirus type 16 capsid antibodies among a cohort of university women

Joseph J. Carter, Laura A. Koutsky, Gregory C. Wipf, Neil Christensen, Shu Kuang Lee, Jane Kuypers, Nancy Kiviat, Denise A. Galloway

Research output: Contribution to journalArticle

256 Citations (Scopus)

Abstract

To study the temporal relationship between serum antibody response and human papillomavirus type 16 (HPV-16) infection, a cohort of 325 university women were scheduled for examinations at 4-month intervals. At every examination, interviews were completed, cells were obtained for polymerase chain reaction-based testing and for Pap screening, and serum was obtained for testing with a HPV-16 capsid-capture ELISA. Seroreactivity was associated with detection of HPV-16 DNA and with increased numbers of sex partners. The median time to seroconversion was 8.3 months among women with incident HPV- 16 infections. Within 16 months following HPV-16 DNA detection, 93.7% of women with prevalent and 67.1% of women with incident infections seroconverted. After seroconversion, antibody responses were maintained during follow-up among HPV-16 DNA-positive women. Women who seroconverted were 5.7 times (95% confidence interval = 2.4-13.4) more likely to have squamous intraepithelial lesions associated with the detection of HPV-16 DNA than were women who did not seroconvert.

Original languageEnglish (US)
Pages (from-to)927-936
Number of pages10
JournalJournal of Infectious Diseases
Volume174
Issue number5
DOIs
StatePublished - Jan 1 1996

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Human papillomavirus 16
Capsid
Natural History
Antibodies
DNA
Antibody Formation
Papillomavirus Infections
Infection
Serum
Enzyme-Linked Immunosorbent Assay
Confidence Intervals
Interviews
Polymerase Chain Reaction

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Carter, Joseph J. ; Koutsky, Laura A. ; Wipf, Gregory C. ; Christensen, Neil ; Lee, Shu Kuang ; Kuypers, Jane ; Kiviat, Nancy ; Galloway, Denise A. / The natural history of human papillomavirus type 16 capsid antibodies among a cohort of university women. In: Journal of Infectious Diseases. 1996 ; Vol. 174, No. 5. pp. 927-936.
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The natural history of human papillomavirus type 16 capsid antibodies among a cohort of university women. / Carter, Joseph J.; Koutsky, Laura A.; Wipf, Gregory C.; Christensen, Neil; Lee, Shu Kuang; Kuypers, Jane; Kiviat, Nancy; Galloway, Denise A.

In: Journal of Infectious Diseases, Vol. 174, No. 5, 01.01.1996, p. 927-936.

Research output: Contribution to journalArticle

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