The nature of processing speed deficits in traumatic brain injury

Is less brain more?

Frank Gerard Hillary, Helen M. Genova, John D. Medaglia, Neal M. Fitzpatrick, Kathy S. Chiou, Britney Wardecker, Robert G. Franklin, Jian-li Wang, John DeLuca

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

The cognitive constructs working memory (WM) and processing speed are fundamental components to general intellectual functioning in humans and highly susceptible to disruption following neurological insult. Much of the work to date examining speeded working memory deficits in clinical samples using functional imaging has demonstrated recruitment of network areas including prefrontal cortex (PFC) and anterior cingulate cortex (ACC). What remains unclear is the nature of this neural recruitment. The goal of this study was to isolate the neural networks distinct from those evident in healthy adults and to determine if reaction time (RT) reliably predicts observable between-group differences. The current data indicate that much of the neural recruitment in TBI during a speeded visual scanning task is positively correlated with RT. These data indicate that recruitment in PFC during tasks of rapid information processing are at least partially attributable to normal recruitment of PFC support resources during slowed task processing.

Original languageEnglish (US)
Pages (from-to)141-154
Number of pages14
JournalBrain Imaging and Behavior
Volume4
Issue number2
DOIs
StatePublished - Apr 30 2010

Fingerprint

Prefrontal Cortex
Short-Term Memory
Reaction Time
Brain
Gyrus Cinguli
Memory Disorders
Automatic Data Processing
Traumatic Brain Injury

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology
  • Cognitive Neuroscience
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience
  • Behavioral Neuroscience

Cite this

Hillary, Frank Gerard ; Genova, Helen M. ; Medaglia, John D. ; Fitzpatrick, Neal M. ; Chiou, Kathy S. ; Wardecker, Britney ; Franklin, Robert G. ; Wang, Jian-li ; DeLuca, John. / The nature of processing speed deficits in traumatic brain injury : Is less brain more?. In: Brain Imaging and Behavior. 2010 ; Vol. 4, No. 2. pp. 141-154.
@article{87c054bf34b942df8a88885ac7c98111,
title = "The nature of processing speed deficits in traumatic brain injury: Is less brain more?",
abstract = "The cognitive constructs working memory (WM) and processing speed are fundamental components to general intellectual functioning in humans and highly susceptible to disruption following neurological insult. Much of the work to date examining speeded working memory deficits in clinical samples using functional imaging has demonstrated recruitment of network areas including prefrontal cortex (PFC) and anterior cingulate cortex (ACC). What remains unclear is the nature of this neural recruitment. The goal of this study was to isolate the neural networks distinct from those evident in healthy adults and to determine if reaction time (RT) reliably predicts observable between-group differences. The current data indicate that much of the neural recruitment in TBI during a speeded visual scanning task is positively correlated with RT. These data indicate that recruitment in PFC during tasks of rapid information processing are at least partially attributable to normal recruitment of PFC support resources during slowed task processing.",
author = "Hillary, {Frank Gerard} and Genova, {Helen M.} and Medaglia, {John D.} and Fitzpatrick, {Neal M.} and Chiou, {Kathy S.} and Britney Wardecker and Franklin, {Robert G.} and Jian-li Wang and John DeLuca",
year = "2010",
month = "4",
day = "30",
doi = "10.1007/s11682-010-9094-z",
language = "English (US)",
volume = "4",
pages = "141--154",
journal = "Brain Imaging and Behavior",
issn = "1931-7557",
publisher = "Springer New York",
number = "2",

}

The nature of processing speed deficits in traumatic brain injury : Is less brain more? / Hillary, Frank Gerard; Genova, Helen M.; Medaglia, John D.; Fitzpatrick, Neal M.; Chiou, Kathy S.; Wardecker, Britney; Franklin, Robert G.; Wang, Jian-li; DeLuca, John.

In: Brain Imaging and Behavior, Vol. 4, No. 2, 30.04.2010, p. 141-154.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The nature of processing speed deficits in traumatic brain injury

T2 - Is less brain more?

AU - Hillary, Frank Gerard

AU - Genova, Helen M.

AU - Medaglia, John D.

AU - Fitzpatrick, Neal M.

AU - Chiou, Kathy S.

AU - Wardecker, Britney

AU - Franklin, Robert G.

AU - Wang, Jian-li

AU - DeLuca, John

PY - 2010/4/30

Y1 - 2010/4/30

N2 - The cognitive constructs working memory (WM) and processing speed are fundamental components to general intellectual functioning in humans and highly susceptible to disruption following neurological insult. Much of the work to date examining speeded working memory deficits in clinical samples using functional imaging has demonstrated recruitment of network areas including prefrontal cortex (PFC) and anterior cingulate cortex (ACC). What remains unclear is the nature of this neural recruitment. The goal of this study was to isolate the neural networks distinct from those evident in healthy adults and to determine if reaction time (RT) reliably predicts observable between-group differences. The current data indicate that much of the neural recruitment in TBI during a speeded visual scanning task is positively correlated with RT. These data indicate that recruitment in PFC during tasks of rapid information processing are at least partially attributable to normal recruitment of PFC support resources during slowed task processing.

AB - The cognitive constructs working memory (WM) and processing speed are fundamental components to general intellectual functioning in humans and highly susceptible to disruption following neurological insult. Much of the work to date examining speeded working memory deficits in clinical samples using functional imaging has demonstrated recruitment of network areas including prefrontal cortex (PFC) and anterior cingulate cortex (ACC). What remains unclear is the nature of this neural recruitment. The goal of this study was to isolate the neural networks distinct from those evident in healthy adults and to determine if reaction time (RT) reliably predicts observable between-group differences. The current data indicate that much of the neural recruitment in TBI during a speeded visual scanning task is positively correlated with RT. These data indicate that recruitment in PFC during tasks of rapid information processing are at least partially attributable to normal recruitment of PFC support resources during slowed task processing.

UR - http://www.scopus.com/inward/record.url?scp=77953534663&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77953534663&partnerID=8YFLogxK

U2 - 10.1007/s11682-010-9094-z

DO - 10.1007/s11682-010-9094-z

M3 - Article

VL - 4

SP - 141

EP - 154

JO - Brain Imaging and Behavior

JF - Brain Imaging and Behavior

SN - 1931-7557

IS - 2

ER -