The neural basis for sleep regulation - Data assimilation from animal to model

Fatemeh Bahari, Camila Tulyaganova, Myles Billard, Kevin Alloway, Bruce Gluckman

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Sleep is important for normal brain function, and sleep disruption is comorbid with many neurological diseases. There is a growing mechanistic understanding of the neurological basis for sleep regulation that is beginning to lead to mechanistic mathematically described models. It is our objective to validate the predictive capacity of such models using data assimilation (DA) methods. If such methods are successful, and the models accurately describe enough of the mechanistic functions of the physical system, then they can be used as sophisticated observation systems to reveal both system changes and sources of dysfunction with neurological diseases and identify routes to intervene. Here we report on extensions to our initial efforts [1] at applying unscented Kalman Filter (UKF) to models of sleep regulation on three fronts: tools for multi-parameter fitting; a sophisticated observation model to apply the UKF for observations of behavioral state; and comparison with data recorded from brainstem cell groups thought to regulate sleep.

Original languageEnglish (US)
Title of host publicationConference Record of the 50th Asilomar Conference on Signals, Systems and Computers, ACSSC 2016
EditorsMichael B. Matthews
PublisherIEEE Computer Society
Pages1061-1065
Number of pages5
ISBN (Electronic)9781538639542
DOIs
StatePublished - Mar 1 2017
Event50th Asilomar Conference on Signals, Systems and Computers, ACSSC 2016 - Pacific Grove, United States
Duration: Nov 6 2016Nov 9 2016

Publication series

NameConference Record - Asilomar Conference on Signals, Systems and Computers
ISSN (Print)1058-6393

Other

Other50th Asilomar Conference on Signals, Systems and Computers, ACSSC 2016
CountryUnited States
CityPacific Grove
Period11/6/1611/9/16

Fingerprint

Animals
Kalman filters
Brain
Sleep

All Science Journal Classification (ASJC) codes

  • Signal Processing
  • Computer Networks and Communications

Cite this

Bahari, F., Tulyaganova, C., Billard, M., Alloway, K., & Gluckman, B. (2017). The neural basis for sleep regulation - Data assimilation from animal to model. In M. B. Matthews (Ed.), Conference Record of the 50th Asilomar Conference on Signals, Systems and Computers, ACSSC 2016 (pp. 1061-1065). [7869532] (Conference Record - Asilomar Conference on Signals, Systems and Computers). IEEE Computer Society. https://doi.org/10.1109/ACSSC.2016.7869532
Bahari, Fatemeh ; Tulyaganova, Camila ; Billard, Myles ; Alloway, Kevin ; Gluckman, Bruce. / The neural basis for sleep regulation - Data assimilation from animal to model. Conference Record of the 50th Asilomar Conference on Signals, Systems and Computers, ACSSC 2016. editor / Michael B. Matthews. IEEE Computer Society, 2017. pp. 1061-1065 (Conference Record - Asilomar Conference on Signals, Systems and Computers).
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Bahari, F, Tulyaganova, C, Billard, M, Alloway, K & Gluckman, B 2017, The neural basis for sleep regulation - Data assimilation from animal to model. in MB Matthews (ed.), Conference Record of the 50th Asilomar Conference on Signals, Systems and Computers, ACSSC 2016., 7869532, Conference Record - Asilomar Conference on Signals, Systems and Computers, IEEE Computer Society, pp. 1061-1065, 50th Asilomar Conference on Signals, Systems and Computers, ACSSC 2016, Pacific Grove, United States, 11/6/16. https://doi.org/10.1109/ACSSC.2016.7869532

The neural basis for sleep regulation - Data assimilation from animal to model. / Bahari, Fatemeh; Tulyaganova, Camila; Billard, Myles; Alloway, Kevin; Gluckman, Bruce.

Conference Record of the 50th Asilomar Conference on Signals, Systems and Computers, ACSSC 2016. ed. / Michael B. Matthews. IEEE Computer Society, 2017. p. 1061-1065 7869532 (Conference Record - Asilomar Conference on Signals, Systems and Computers).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Bahari F, Tulyaganova C, Billard M, Alloway K, Gluckman B. The neural basis for sleep regulation - Data assimilation from animal to model. In Matthews MB, editor, Conference Record of the 50th Asilomar Conference on Signals, Systems and Computers, ACSSC 2016. IEEE Computer Society. 2017. p. 1061-1065. 7869532. (Conference Record - Asilomar Conference on Signals, Systems and Computers). https://doi.org/10.1109/ACSSC.2016.7869532