TY - JOUR
T1 - The neural basis of recollection rejection
T2 - Increases in hippocampal–prefrontal connectivity in the absence of a shared recall-to-reject and target recollection network
AU - Bowman, Caitlin R.
AU - Dennis, Nancy A.
N1 - Funding Information:
We thank the Penn State Social, Life, & Engineering Sciences Imaging Center (SLEIC), 3T MRI Facility. We also thank Christina Webb, John Huhn, Kyle Kurkela, and Indira Turney for helpful comments throughout the project and during the writing process and Shalome Sine for assistance with data collection. This work was supported by a National Science Foundation grant BCS1025709 awarded to N. A. D. It was also supported by dissertation awards granted by the American Psychological Association and Penn State’s Research and Graduate Studies Office to C. R. B.
Publisher Copyright:
© 2016 Massachusetts Institute of Technology.
PY - 2016/8/1
Y1 - 2016/8/1
N2 - Recollection rejection or “recall-to-reject” is a mechanism that has been posited to help maintain accurate memory by preventing the occurrence of false memories. Recollection rejection occurs when the presentation of a new item during recognition triggers recall of an associated target, a mismatch in features between the new and old items is registered, and the lure is correctly rejected. Critically, this characterization of recollection rejection involves a recall signal that is conceptually similar to recollection as elicited by a target. However, previous neuroimaging studies have not evaluated the extent to which recollection rejection and target recollection rely on a common neural signal but have instead focused on recollection rejection as a postretrieval monitoring process. This study utilized a false memory paradigm in conjunction with an adapted remember–know–new response paradigm that separated “new” responses based on recollection rejection from those that were based on a lack of familiarity with the item. This procedure allowed for parallel recollection rejection and target recollection contrasts to be computed. Results revealed that, contrary to predictions from theoretical and behavioral literature, there was virtually no evidence of a common retrieval mechanism supporting recollection rejection and target recollection. Instead of the typical target recollection network, recollection rejection recruited a network of lateral prefrontal and bilateral parietal regions that is consistent with the retrieval monitoring network identified in previous neuroimaging studies of recollection rejection. However, a functional connectivity analysis revealed a component of the frontoparietal rejection network that showed increased coupling with the right hippocampus during recollection rejection responses. As such, we demonstrate a possible link between PFC monitoring network and basic retrieval mechanisms within the hippocampus that was not revealed with univariate analyses alone.
AB - Recollection rejection or “recall-to-reject” is a mechanism that has been posited to help maintain accurate memory by preventing the occurrence of false memories. Recollection rejection occurs when the presentation of a new item during recognition triggers recall of an associated target, a mismatch in features between the new and old items is registered, and the lure is correctly rejected. Critically, this characterization of recollection rejection involves a recall signal that is conceptually similar to recollection as elicited by a target. However, previous neuroimaging studies have not evaluated the extent to which recollection rejection and target recollection rely on a common neural signal but have instead focused on recollection rejection as a postretrieval monitoring process. This study utilized a false memory paradigm in conjunction with an adapted remember–know–new response paradigm that separated “new” responses based on recollection rejection from those that were based on a lack of familiarity with the item. This procedure allowed for parallel recollection rejection and target recollection contrasts to be computed. Results revealed that, contrary to predictions from theoretical and behavioral literature, there was virtually no evidence of a common retrieval mechanism supporting recollection rejection and target recollection. Instead of the typical target recollection network, recollection rejection recruited a network of lateral prefrontal and bilateral parietal regions that is consistent with the retrieval monitoring network identified in previous neuroimaging studies of recollection rejection. However, a functional connectivity analysis revealed a component of the frontoparietal rejection network that showed increased coupling with the right hippocampus during recollection rejection responses. As such, we demonstrate a possible link between PFC monitoring network and basic retrieval mechanisms within the hippocampus that was not revealed with univariate analyses alone.
UR - http://www.scopus.com/inward/record.url?scp=84975721618&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84975721618&partnerID=8YFLogxK
U2 - 10.1162/jocn_a_00961
DO - 10.1162/jocn_a_00961
M3 - Article
C2 - 27054401
AN - SCOPUS:84975721618
VL - 28
SP - 1194
EP - 1209
JO - Journal of Cognitive Neuroscience
JF - Journal of Cognitive Neuroscience
SN - 0898-929X
IS - 8
ER -