The neuronal influence on retinal vascular pathology

Alistair Barber, Heather D. Van Guilder, Matthew J. Gastinger

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Much of the effort to understand diabetic retinopathy has focused on vascular pathology. Due to the influence of diabetes on systemic physiology, it is thought that many changes in retinal vascular cells likely stem from direct biochemical disruptions such as hyperglycemia. Other contributing factors may include circulating cytokines, advanced glycation end products, cholesterol, albumin, and electrolytes, and more complex functional changes such as reduced elasticity in erythrocytes and other blood cells. These and other changes could be responsible for generating the vascular pathologies that have been well established in diabetic retinopathy. There is increasing evidence, however, for involvement of the neural elements of the retina, the neurons and glial cells, and it is no longer clear if the pathological changes in these cells result from vascular dysfunction, such as the reduction in effectiveness of the blood-retinal barrier, or if diabetic physiology induces neural pathology, which in turn gives rise to vascular changes. A third possibility is that early vascular and neural responses to diabetes are independent phenomena that are triggered by different factors.

Original languageEnglish (US)
Title of host publicationRetinal Vascular Disease
PublisherSpringer Berlin Heidelberg
Pages108-120
Number of pages13
ISBN (Print)9783540295419
DOIs
StatePublished - Dec 1 2007

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Retinal Vessels
Blood Vessels
Pathology
Diabetic Retinopathy
Blood-Retinal Barrier
Advanced Glycosylation End Products
Elasticity
Neuroglia
Hyperglycemia
Electrolytes
Retina
Albumins
Blood Cells
Stem Cells
Erythrocytes
Cholesterol
Cytokines
Neurons

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Barber, A., Van Guilder, H. D., & Gastinger, M. J. (2007). The neuronal influence on retinal vascular pathology. In Retinal Vascular Disease (pp. 108-120). Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-540-29542-6_6
Barber, Alistair ; Van Guilder, Heather D. ; Gastinger, Matthew J. / The neuronal influence on retinal vascular pathology. Retinal Vascular Disease. Springer Berlin Heidelberg, 2007. pp. 108-120
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Barber, A, Van Guilder, HD & Gastinger, MJ 2007, The neuronal influence on retinal vascular pathology. in Retinal Vascular Disease. Springer Berlin Heidelberg, pp. 108-120. https://doi.org/10.1007/978-3-540-29542-6_6

The neuronal influence on retinal vascular pathology. / Barber, Alistair; Van Guilder, Heather D.; Gastinger, Matthew J.

Retinal Vascular Disease. Springer Berlin Heidelberg, 2007. p. 108-120.

Research output: Chapter in Book/Report/Conference proceedingChapter

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Barber A, Van Guilder HD, Gastinger MJ. The neuronal influence on retinal vascular pathology. In Retinal Vascular Disease. Springer Berlin Heidelberg. 2007. p. 108-120 https://doi.org/10.1007/978-3-540-29542-6_6