The neuroprotective and angiogenesis inhibitory serpin, PEDF: New insights into phylogeny, function, and signaling

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Pigment Epithelial-Derived Factor (PEDF) is a non inhibitory serpin with neuroprotective and antiangiogenic actions. It is a potent and broadly acting neurotrophic factor that protects neurons from many regions of the CNS against a wide range of neurodegenerative insults including glutamate toxicity and oxidative stress. PEDF also functions as a natural inhibitor of angiogenesis, targeting the growth of only new vessels. The 50 kD protein is encoded by a single gene that shows strong conservation across phyla from fish to mammals. Two specific domains on the PEDF protein interact with extracellular matrix components and may mediate some of the biological actions of this protein. The transducers through which PEDF signals neurons and endothelial cells are defined and involves major pathways including Akt/NFκB , MAPK, and the caspases. PEDF is widely expressed in the nervous system and in most tissues of the body. A significant amount of the protein is found in the cerebral spinal fluid and circulating plasma as well. Therapeutic administration of the soluble protein or viral-mediated transfer of the gene in experimental in vivo models suggests that PEDF is an excellent pharmacological tool for slowing the progression of a range of neurodegenerative diseases and those pathologies associated with abnormal vessel growth in the eye and metastatic cancers of various tissues.

Original languageEnglish (US)
Pages (from-to)2131-2149
Number of pages19
JournalFrontiers in Bioscience
Volume10
Issue numberSUPPL. 1
DOIs
StatePublished - Jan 1 2005

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Serpins
Phylogeny
Pigments
Proteins
Eye Neoplasms
Neurons
Angiogenesis Inhibitors
Nerve Growth Factors
Viral Proteins
Growth
Caspases
Genes
Transducers
Neurodegenerative Diseases
Neurodegenerative diseases
Tissue
Nervous System
Extracellular Matrix
Glutamic Acid
Mammals

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

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The neuroprotective and angiogenesis inhibitory serpin, PEDF : New insights into phylogeny, function, and signaling. / Tombran-Tink, Joyce.

In: Frontiers in Bioscience, Vol. 10, No. SUPPL. 1, 01.01.2005, p. 2131-2149.

Research output: Contribution to journalArticle

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