The oral administration of MnCl 2: A potential alternative to IV injection for tissue contrast enhancement in magnetic resonance imaging

Keith R. Burnett, Edward J. Goldstein, Gerald L. Wolf, Swapan Sen, Alexander Mamourian

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Mn +2 (as MnCl 2 ) was administered to rabbits intravenously and orally (a route of administration which based upon our previous experiments in rats 7 promises to give selective hepatobiliary enhancement with less systemic toxicity). Nuclear magnetic relaxation dispersion or T 1 (NMRD) was performed on selected tissues (heart, liver, kidney, serum, and bile) in both animal groups to examine possible qualitative and semiquantitative differences in T 1 relaxation at equivalent sacrifice times. One animal was given an oral dose of MnCl 2 (620 micromoles/kg) and imaged sequentially (T 1 weighted sequence, .12T) for 30 minutes. The NMRD curves for organ tissues show an increase in relaxation efficacy in the 10-20MHz range characteristic of Mn-macromolecular complexes and are similar irrespective of the route of administration. The lack of increased relaxation enhancement for bile in this frequency range reflects cleavage of this complex upon excretion. Decreased overall relaxation in the liver is observed when oral Mn +2 is compared to IV Mn +2 due to the small fraction of administered dose that is absorbed. However, the images document a significant increase in the intensity of liver signal after the oral dose. We suspect this dose may ultimately be adjusted downward to give selective hepatobiliary effects.

Original languageEnglish (US)
Pages (from-to)307-314
Number of pages8
JournalMagnetic Resonance Imaging
Volume2
Issue number4
DOIs
StatePublished - Jan 1 1984

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Magnetic resonance
Liver
Magnetic relaxation
Oral Administration
Magnetic Resonance Imaging
Tissue
Imaging techniques
Bile
Injections
Animals
Macromolecular Substances
Toxicity
Rats
Rabbits
Kidney
Serum
Experiments

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

Cite this

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abstract = "Mn +2 (as MnCl 2 ) was administered to rabbits intravenously and orally (a route of administration which based upon our previous experiments in rats 7 promises to give selective hepatobiliary enhancement with less systemic toxicity). Nuclear magnetic relaxation dispersion or T 1 (NMRD) was performed on selected tissues (heart, liver, kidney, serum, and bile) in both animal groups to examine possible qualitative and semiquantitative differences in T 1 relaxation at equivalent sacrifice times. One animal was given an oral dose of MnCl 2 (620 micromoles/kg) and imaged sequentially (T 1 weighted sequence, .12T) for 30 minutes. The NMRD curves for organ tissues show an increase in relaxation efficacy in the 10-20MHz range characteristic of Mn-macromolecular complexes and are similar irrespective of the route of administration. The lack of increased relaxation enhancement for bile in this frequency range reflects cleavage of this complex upon excretion. Decreased overall relaxation in the liver is observed when oral Mn +2 is compared to IV Mn +2 due to the small fraction of administered dose that is absorbed. However, the images document a significant increase in the intensity of liver signal after the oral dose. We suspect this dose may ultimately be adjusted downward to give selective hepatobiliary effects.",
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The oral administration of MnCl 2 : A potential alternative to IV injection for tissue contrast enhancement in magnetic resonance imaging. / Burnett, Keith R.; Goldstein, Edward J.; Wolf, Gerald L.; Sen, Swapan; Mamourian, Alexander.

In: Magnetic Resonance Imaging, Vol. 2, No. 4, 01.01.1984, p. 307-314.

Research output: Contribution to journalArticle

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