The oxytocin receptor (OXTR) contributes to prosocial fund allocations in the Dictator Game and the social value orientations task

Salomon Israel, Elad Lerer, Idan Shalev, Florina Uzefovsky, Mathias Riebold, Efrat Laiba, Rachel Bachner-Melman, Anat Maril, Gary Bornstein, Ariel Knafo, Richard P. Ebstein

Research output: Contribution to journalArticle

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Abstract

Background: Economic games observe social decision making in the laboratory that involves real money payoffs. Previously we have shown that allocation of funds in the Dictator Game (DG), a paradigm that illustrates costly altruistic behavior, is partially determined by promoter-region repeat region variants in the arginine vasopressin 1a receptor gene (AVPR1a). In the current investigation, the gene encoding the related oxytocin receptor (OXTR) was tested for association with the DG and a related paradigm, the Social Values Orientation (SVO) task. Methodology/Principal Findings: Association (101 male and 102 female students) using a robust-family based test between 15 single tagging SNPs (htSNPs) across the OXTR was demonstrated with both the DG and SVO. Three htSNPs across the gene region showed significant association with both of the two games. The most significant association was observed with rs1042778 (p=0.001). Haplotype analysis also showed significant associations for both DG and SVO. Following permutation test adjustment, significance was observed for 2-5 locus haplotypes (p<0.05). A second sample of 98 female subjects was subsequently and independently recruited to play the dictator game and was genotyped for the three significant SNPs found in the first sample. The rs1042778 SNP was shown to be significant for the second sample as well (p=0.004, Fisher's exact test). Conclusions: The demonstration that genetic polymorphisms for the OXTR are associated with human prosocial decision making converges with a large body of animal research showing that oxytocin is an important social hormone across vertebrates including Homo sapiens. Individual differences in prosocial behavior have been shown by twin studies to have a substantial genetic basis and the current investigation demonstrates that common variants in the oxytocin receptor gene, an important element of mammalian social circuitry, underlie such individual differences.

Original languageEnglish (US)
Article numbere5535
JournalPloS one
Volume4
Issue number5
DOIs
StatePublished - May 20 2009

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Oxytocin Receptors
Social Values
social benefit
Financial Management
Genes
Single Nucleotide Polymorphism
decision making
haplotypes
genes
Decision making
arginine vasopressin
Individuality
Haplotypes
animal research
Gene encoding
Arginine Vasopressin
oxytocin
Decision Making
testing
Oxytocin

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Israel, Salomon ; Lerer, Elad ; Shalev, Idan ; Uzefovsky, Florina ; Riebold, Mathias ; Laiba, Efrat ; Bachner-Melman, Rachel ; Maril, Anat ; Bornstein, Gary ; Knafo, Ariel ; Ebstein, Richard P. / The oxytocin receptor (OXTR) contributes to prosocial fund allocations in the Dictator Game and the social value orientations task. In: PloS one. 2009 ; Vol. 4, No. 5.
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title = "The oxytocin receptor (OXTR) contributes to prosocial fund allocations in the Dictator Game and the social value orientations task",
abstract = "Background: Economic games observe social decision making in the laboratory that involves real money payoffs. Previously we have shown that allocation of funds in the Dictator Game (DG), a paradigm that illustrates costly altruistic behavior, is partially determined by promoter-region repeat region variants in the arginine vasopressin 1a receptor gene (AVPR1a). In the current investigation, the gene encoding the related oxytocin receptor (OXTR) was tested for association with the DG and a related paradigm, the Social Values Orientation (SVO) task. Methodology/Principal Findings: Association (101 male and 102 female students) using a robust-family based test between 15 single tagging SNPs (htSNPs) across the OXTR was demonstrated with both the DG and SVO. Three htSNPs across the gene region showed significant association with both of the two games. The most significant association was observed with rs1042778 (p=0.001). Haplotype analysis also showed significant associations for both DG and SVO. Following permutation test adjustment, significance was observed for 2-5 locus haplotypes (p<0.05). A second sample of 98 female subjects was subsequently and independently recruited to play the dictator game and was genotyped for the three significant SNPs found in the first sample. The rs1042778 SNP was shown to be significant for the second sample as well (p=0.004, Fisher's exact test). Conclusions: The demonstration that genetic polymorphisms for the OXTR are associated with human prosocial decision making converges with a large body of animal research showing that oxytocin is an important social hormone across vertebrates including Homo sapiens. Individual differences in prosocial behavior have been shown by twin studies to have a substantial genetic basis and the current investigation demonstrates that common variants in the oxytocin receptor gene, an important element of mammalian social circuitry, underlie such individual differences.",
author = "Salomon Israel and Elad Lerer and Idan Shalev and Florina Uzefovsky and Mathias Riebold and Efrat Laiba and Rachel Bachner-Melman and Anat Maril and Gary Bornstein and Ariel Knafo and Ebstein, {Richard P.}",
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Israel, S, Lerer, E, Shalev, I, Uzefovsky, F, Riebold, M, Laiba, E, Bachner-Melman, R, Maril, A, Bornstein, G, Knafo, A & Ebstein, RP 2009, 'The oxytocin receptor (OXTR) contributes to prosocial fund allocations in the Dictator Game and the social value orientations task', PloS one, vol. 4, no. 5, e5535. https://doi.org/10.1371/journal.pone.0005535

The oxytocin receptor (OXTR) contributes to prosocial fund allocations in the Dictator Game and the social value orientations task. / Israel, Salomon; Lerer, Elad; Shalev, Idan; Uzefovsky, Florina; Riebold, Mathias; Laiba, Efrat; Bachner-Melman, Rachel; Maril, Anat; Bornstein, Gary; Knafo, Ariel; Ebstein, Richard P.

In: PloS one, Vol. 4, No. 5, e5535, 20.05.2009.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The oxytocin receptor (OXTR) contributes to prosocial fund allocations in the Dictator Game and the social value orientations task

AU - Israel, Salomon

AU - Lerer, Elad

AU - Shalev, Idan

AU - Uzefovsky, Florina

AU - Riebold, Mathias

AU - Laiba, Efrat

AU - Bachner-Melman, Rachel

AU - Maril, Anat

AU - Bornstein, Gary

AU - Knafo, Ariel

AU - Ebstein, Richard P.

PY - 2009/5/20

Y1 - 2009/5/20

N2 - Background: Economic games observe social decision making in the laboratory that involves real money payoffs. Previously we have shown that allocation of funds in the Dictator Game (DG), a paradigm that illustrates costly altruistic behavior, is partially determined by promoter-region repeat region variants in the arginine vasopressin 1a receptor gene (AVPR1a). In the current investigation, the gene encoding the related oxytocin receptor (OXTR) was tested for association with the DG and a related paradigm, the Social Values Orientation (SVO) task. Methodology/Principal Findings: Association (101 male and 102 female students) using a robust-family based test between 15 single tagging SNPs (htSNPs) across the OXTR was demonstrated with both the DG and SVO. Three htSNPs across the gene region showed significant association with both of the two games. The most significant association was observed with rs1042778 (p=0.001). Haplotype analysis also showed significant associations for both DG and SVO. Following permutation test adjustment, significance was observed for 2-5 locus haplotypes (p<0.05). A second sample of 98 female subjects was subsequently and independently recruited to play the dictator game and was genotyped for the three significant SNPs found in the first sample. The rs1042778 SNP was shown to be significant for the second sample as well (p=0.004, Fisher's exact test). Conclusions: The demonstration that genetic polymorphisms for the OXTR are associated with human prosocial decision making converges with a large body of animal research showing that oxytocin is an important social hormone across vertebrates including Homo sapiens. Individual differences in prosocial behavior have been shown by twin studies to have a substantial genetic basis and the current investigation demonstrates that common variants in the oxytocin receptor gene, an important element of mammalian social circuitry, underlie such individual differences.

AB - Background: Economic games observe social decision making in the laboratory that involves real money payoffs. Previously we have shown that allocation of funds in the Dictator Game (DG), a paradigm that illustrates costly altruistic behavior, is partially determined by promoter-region repeat region variants in the arginine vasopressin 1a receptor gene (AVPR1a). In the current investigation, the gene encoding the related oxytocin receptor (OXTR) was tested for association with the DG and a related paradigm, the Social Values Orientation (SVO) task. Methodology/Principal Findings: Association (101 male and 102 female students) using a robust-family based test between 15 single tagging SNPs (htSNPs) across the OXTR was demonstrated with both the DG and SVO. Three htSNPs across the gene region showed significant association with both of the two games. The most significant association was observed with rs1042778 (p=0.001). Haplotype analysis also showed significant associations for both DG and SVO. Following permutation test adjustment, significance was observed for 2-5 locus haplotypes (p<0.05). A second sample of 98 female subjects was subsequently and independently recruited to play the dictator game and was genotyped for the three significant SNPs found in the first sample. The rs1042778 SNP was shown to be significant for the second sample as well (p=0.004, Fisher's exact test). Conclusions: The demonstration that genetic polymorphisms for the OXTR are associated with human prosocial decision making converges with a large body of animal research showing that oxytocin is an important social hormone across vertebrates including Homo sapiens. Individual differences in prosocial behavior have been shown by twin studies to have a substantial genetic basis and the current investigation demonstrates that common variants in the oxytocin receptor gene, an important element of mammalian social circuitry, underlie such individual differences.

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