The paradoxical effects of vitamin D on type 1 mediated immunity

Margherita Teresa-Anna Cantorna, Sanhong Yu, Danny Bruce

Research output: Contribution to journalReview article

83 Citations (Scopus)

Abstract

Low vitamin D status is associated with an increased risk of Th1 mediated autoimmune diseases like inflammatory bowel disease. 1,25(OH)2D3 treatments have been shown to suppress Th1 mediated immunity and protect animals from experimental autoimmunity. Th1 mediated immunity is important for clearance of a number of different infectious diseases. For tuberculosis 1,25(OH)2D3 treatment is associated with decreased Th1 mediated immunity but increased bactericidal activity. Systemic candidiasis is unaffected by 1,25(OH)2D3 treatment. The seemingly paradoxical effects of 1,25(OH)2D3 and vitamin D on Th1 mediated autoimmunity versus infectious immunity point to a broad array of vitamin D targets in the immune system. The interplay of these vitamin D targets and their impact on the host-immune response then dictate the outcome.

Original languageEnglish (US)
Pages (from-to)369-375
Number of pages7
JournalMolecular Aspects of Medicine
Volume29
Issue number6
DOIs
StatePublished - Dec 1 2008

Fingerprint

Vitamin D
Immunity
Autoimmunity
Immune system
Inflammatory Bowel Diseases
Autoimmune Diseases
Communicable Diseases
Immune System
Animals
Tuberculosis

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Molecular Medicine
  • Clinical Biochemistry
  • Medicine(all)

Cite this

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The paradoxical effects of vitamin D on type 1 mediated immunity. / Cantorna, Margherita Teresa-Anna; Yu, Sanhong; Bruce, Danny.

In: Molecular Aspects of Medicine, Vol. 29, No. 6, 01.12.2008, p. 369-375.

Research output: Contribution to journalReview article

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