The parallel rod floor test: A measure of ataxia in mice

Helen Marie Kamens, John C. Crabbe

    Research output: Contribution to journalArticle

    29 Citations (Scopus)

    Abstract

    The parallel rod floor test is a new model of ataxia in mice. It allows the simultaneous measurement of ataxia and locomotor activity. This protocol is designed for researchers examining ethanol-induced motor incoordination in mice, but it should be applicable to other sedative/hypnotic drugs and to testing cerebellar mutant mice or mice with engineered genetic defects. This protocol takes 3 d, with the time per day depending on how many animals are tested. The test allows researchers to quantify differences in motor coordination among genotypes of mice that may differ in locomotor activity. Unlike many other methods for assessing incoordination, the parallel rod floor test yields similar patterns of genetic sensitivity across a range of variant forms of the apparatus.

    Original languageEnglish (US)
    Pages (from-to)277-281
    Number of pages5
    JournalNature Protocols
    Volume2
    Issue number2
    DOIs
    StatePublished - Mar 1 2007

    Fingerprint

    Ataxia
    Hypnotics and Sedatives
    Locomotion
    Animals
    Ethanol
    Defects
    Research Personnel
    Testing
    Pharmaceutical Preparations
    Genotype

    All Science Journal Classification (ASJC) codes

    • Biochemistry, Genetics and Molecular Biology(all)

    Cite this

    Kamens, Helen Marie ; Crabbe, John C. / The parallel rod floor test : A measure of ataxia in mice. In: Nature Protocols. 2007 ; Vol. 2, No. 2. pp. 277-281.
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    The parallel rod floor test : A measure of ataxia in mice. / Kamens, Helen Marie; Crabbe, John C.

    In: Nature Protocols, Vol. 2, No. 2, 01.03.2007, p. 277-281.

    Research output: Contribution to journalArticle

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