Abstract
Objective: The pathogeneses of Chiari malformation type I and syringomyelia are incompletely understood. In this article, the authors attempt to review the current theories on the pathogeneses of Chiari I malformation and syringomyelia. Methods: A literature review for articles pertaining to Chiari I malformation or syringomyelia before August 2010 was conducted; in addition, the author's own experience in treating Chiari I malformation and syringomyelia is included. Results: Chiari I malformation has been defined radiographically as cerebellar tonsillar herniation or ectopia 5 mm or greater below the foramen magnum. By this narrow definition, Chiari I malformation (i.e. cerebellar tonsillar herniation or ectopia 5 mm or greater below the foramen magnum) likely encompasses a heterogeneous grouping of disorders caused by different mechanisms. Molecular and genetic studies have been helpful in furthering our understanding of Chiari I malformation. Conclusion: A review of the pathogeneses of Chiari I malformation and syringomyelia is reported.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 232-239 |
| Number of pages | 8 |
| Journal | Neurological Research |
| Volume | 33 |
| Issue number | 3 |
| DOIs | |
| State | Published - Apr 2011 |
All Science Journal Classification (ASJC) codes
- Neurology
- Clinical Neurology