Abstract

Cortical and subcortical gray matter (GM) atrophy may progress differently during the course of Parkinson’s disease (PD). We delineated and compared the longitudinal pattern of these PD-related changes. Structural MRIs and clinical measures were obtained from 76 PD with different disease durations and 70 Controls at baseline, 18-, and 36 months. Both cortical and subcortical (putamen, caudate, and globus pallidus) GM volumes were obtained, compared, and associated with PD clinical measures at baseline. Their volumes and rates of change also were compared among Controls, PDs, and PD subgroups based on duration of illness [≤1 year (PDE), 1–5 years (PDM), and >5 years (PDL)]. Compared to Controls, PD subjects displayed smaller cortical GM and striatal (putamen, caudate, ps ≤0.001), volumes at baseline. Cortical GM volumes were negatively associated with disease duration at baseline, whereas striatal volumes were not. PD subjects demonstrated accelerated volume loss in cortical GM (p = 0.006), putamen (p = 0.034), and caudate (p = 0.008) compared to Controls. Subgroup analyses demonstrated that accelerated cortical atrophy reached statistical significance in PD subjects with duration of illness 1–5 years (PDM, ps <0.001) and the trend of accelerated atrophy seemed to persist until later stages, whereas striatal atrophy occurred in PD subjects with PDE (p = 0.021 for putamen, p = 0.005 for caudate) and PDM (p = 0.002 for putamen, p = 0.001 for caudate) that significantly slowed down in PDL (ps for PDL vs PDE or PDM: <0.01). The pattern of GM loss in PD differs in cortical and subcortical regions, with striatal atrophy occurring earlier and extra-striatal cortical atrophy later.

Original languageEnglish (US)
Pages (from-to)68-75
Number of pages8
JournalJournal of Neurology
Volume263
Issue number1
DOIs
StatePublished - Jan 1 2016

Fingerprint

Atrophy
Parkinson Disease
Corpus Striatum
Putamen
Gray Matter
Globus Pallidus

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Lewis, Mechelle M. ; Du, Guangwei ; Lee, Eun Young ; Nasralah, Zeinab ; Sterling, Nicholas W. ; Zhang, Lijun ; Wagner, Daymond ; Kong, Lan ; Tröster, Alexander I. ; Styner, Martin ; Eslinger, Paul J. ; Mailman, Richard B. ; Huang, Xuemei. / The pattern of gray matter atrophy in Parkinson’s disease differs in cortical and subcortical regions. In: Journal of Neurology. 2016 ; Vol. 263, No. 1. pp. 68-75.
@article{16f652195a7045478fde0ac97dd6a19a,
title = "The pattern of gray matter atrophy in Parkinson’s disease differs in cortical and subcortical regions",
abstract = "Cortical and subcortical gray matter (GM) atrophy may progress differently during the course of Parkinson’s disease (PD). We delineated and compared the longitudinal pattern of these PD-related changes. Structural MRIs and clinical measures were obtained from 76 PD with different disease durations and 70 Controls at baseline, 18-, and 36 months. Both cortical and subcortical (putamen, caudate, and globus pallidus) GM volumes were obtained, compared, and associated with PD clinical measures at baseline. Their volumes and rates of change also were compared among Controls, PDs, and PD subgroups based on duration of illness [≤1 year (PDE), 1–5 years (PDM), and >5 years (PDL)]. Compared to Controls, PD subjects displayed smaller cortical GM and striatal (putamen, caudate, ps ≤0.001), volumes at baseline. Cortical GM volumes were negatively associated with disease duration at baseline, whereas striatal volumes were not. PD subjects demonstrated accelerated volume loss in cortical GM (p = 0.006), putamen (p = 0.034), and caudate (p = 0.008) compared to Controls. Subgroup analyses demonstrated that accelerated cortical atrophy reached statistical significance in PD subjects with duration of illness 1–5 years (PDM, ps <0.001) and the trend of accelerated atrophy seemed to persist until later stages, whereas striatal atrophy occurred in PD subjects with PDE (p = 0.021 for putamen, p = 0.005 for caudate) and PDM (p = 0.002 for putamen, p = 0.001 for caudate) that significantly slowed down in PDL (ps for PDL vs PDE or PDM: <0.01). The pattern of GM loss in PD differs in cortical and subcortical regions, with striatal atrophy occurring earlier and extra-striatal cortical atrophy later.",
author = "Lewis, {Mechelle M.} and Guangwei Du and Lee, {Eun Young} and Zeinab Nasralah and Sterling, {Nicholas W.} and Lijun Zhang and Daymond Wagner and Lan Kong and Tr{\"o}ster, {Alexander I.} and Martin Styner and Eslinger, {Paul J.} and Mailman, {Richard B.} and Xuemei Huang",
year = "2016",
month = "1",
day = "1",
doi = "10.1007/s00415-015-7929-7",
language = "English (US)",
volume = "263",
pages = "68--75",
journal = "Journal of Neurology",
issn = "0340-5354",
publisher = "D. Steinkopff-Verlag",
number = "1",

}

The pattern of gray matter atrophy in Parkinson’s disease differs in cortical and subcortical regions. / Lewis, Mechelle M.; Du, Guangwei; Lee, Eun Young; Nasralah, Zeinab; Sterling, Nicholas W.; Zhang, Lijun; Wagner, Daymond; Kong, Lan; Tröster, Alexander I.; Styner, Martin; Eslinger, Paul J.; Mailman, Richard B.; Huang, Xuemei.

In: Journal of Neurology, Vol. 263, No. 1, 01.01.2016, p. 68-75.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The pattern of gray matter atrophy in Parkinson’s disease differs in cortical and subcortical regions

AU - Lewis, Mechelle M.

AU - Du, Guangwei

AU - Lee, Eun Young

AU - Nasralah, Zeinab

AU - Sterling, Nicholas W.

AU - Zhang, Lijun

AU - Wagner, Daymond

AU - Kong, Lan

AU - Tröster, Alexander I.

AU - Styner, Martin

AU - Eslinger, Paul J.

AU - Mailman, Richard B.

AU - Huang, Xuemei

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Cortical and subcortical gray matter (GM) atrophy may progress differently during the course of Parkinson’s disease (PD). We delineated and compared the longitudinal pattern of these PD-related changes. Structural MRIs and clinical measures were obtained from 76 PD with different disease durations and 70 Controls at baseline, 18-, and 36 months. Both cortical and subcortical (putamen, caudate, and globus pallidus) GM volumes were obtained, compared, and associated with PD clinical measures at baseline. Their volumes and rates of change also were compared among Controls, PDs, and PD subgroups based on duration of illness [≤1 year (PDE), 1–5 years (PDM), and >5 years (PDL)]. Compared to Controls, PD subjects displayed smaller cortical GM and striatal (putamen, caudate, ps ≤0.001), volumes at baseline. Cortical GM volumes were negatively associated with disease duration at baseline, whereas striatal volumes were not. PD subjects demonstrated accelerated volume loss in cortical GM (p = 0.006), putamen (p = 0.034), and caudate (p = 0.008) compared to Controls. Subgroup analyses demonstrated that accelerated cortical atrophy reached statistical significance in PD subjects with duration of illness 1–5 years (PDM, ps <0.001) and the trend of accelerated atrophy seemed to persist until later stages, whereas striatal atrophy occurred in PD subjects with PDE (p = 0.021 for putamen, p = 0.005 for caudate) and PDM (p = 0.002 for putamen, p = 0.001 for caudate) that significantly slowed down in PDL (ps for PDL vs PDE or PDM: <0.01). The pattern of GM loss in PD differs in cortical and subcortical regions, with striatal atrophy occurring earlier and extra-striatal cortical atrophy later.

AB - Cortical and subcortical gray matter (GM) atrophy may progress differently during the course of Parkinson’s disease (PD). We delineated and compared the longitudinal pattern of these PD-related changes. Structural MRIs and clinical measures were obtained from 76 PD with different disease durations and 70 Controls at baseline, 18-, and 36 months. Both cortical and subcortical (putamen, caudate, and globus pallidus) GM volumes were obtained, compared, and associated with PD clinical measures at baseline. Their volumes and rates of change also were compared among Controls, PDs, and PD subgroups based on duration of illness [≤1 year (PDE), 1–5 years (PDM), and >5 years (PDL)]. Compared to Controls, PD subjects displayed smaller cortical GM and striatal (putamen, caudate, ps ≤0.001), volumes at baseline. Cortical GM volumes were negatively associated with disease duration at baseline, whereas striatal volumes were not. PD subjects demonstrated accelerated volume loss in cortical GM (p = 0.006), putamen (p = 0.034), and caudate (p = 0.008) compared to Controls. Subgroup analyses demonstrated that accelerated cortical atrophy reached statistical significance in PD subjects with duration of illness 1–5 years (PDM, ps <0.001) and the trend of accelerated atrophy seemed to persist until later stages, whereas striatal atrophy occurred in PD subjects with PDE (p = 0.021 for putamen, p = 0.005 for caudate) and PDM (p = 0.002 for putamen, p = 0.001 for caudate) that significantly slowed down in PDL (ps for PDL vs PDE or PDM: <0.01). The pattern of GM loss in PD differs in cortical and subcortical regions, with striatal atrophy occurring earlier and extra-striatal cortical atrophy later.

UR - http://www.scopus.com/inward/record.url?scp=84955742421&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84955742421&partnerID=8YFLogxK

U2 - 10.1007/s00415-015-7929-7

DO - 10.1007/s00415-015-7929-7

M3 - Article

C2 - 26486354

AN - SCOPUS:84955742421

VL - 263

SP - 68

EP - 75

JO - Journal of Neurology

JF - Journal of Neurology

SN - 0340-5354

IS - 1

ER -