The Pharmacokinetics and Pharmacology of Oral Diltiazem in Normal Volunteers

EVLIN L. KINNEY, RALPH M. MOSKOWITZ, ROBERT ZELIS

Research output: Contribution to journalArticle

60 Scopus citations

Abstract

Abstract: Oral diltiazem is being used increasingly in the treatment of Prinzmetal's angina. This study investigated the pharmacokinetics, electrocardiographic effects, and blood pressure response of normal male volunteers to various single oral doses of diltiazem. Doses selected were 30, 60, 90, and 120 mg. Thirteen subjects received 30 mg. 12 subjects received 60 mg, 10 subjects received 90 mg, diltiazem, and four subjects received 120 mg diltiazem AUCs for the 60, 90, and 120 mg doses were 565, 984, and 1258 ng/ml · hr, respectively. The values for t½, β, and tmax were similar after each dosing. 1981 American College of Clinical Pharmacology

Original languageEnglish (US)
Pages (from-to)337-342
Number of pages6
JournalThe Journal of Clinical Pharmacology
Volume21
Issue number8-9
DOIs
StatePublished - Jan 1 1981

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)

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