The pharmacokinetics of chlorinated phenoxy acid herbicides: A literature review

E. K. Arnold, V. R. Beasley

Research output: Contribution to journalReview articlepeer-review

46 Scopus citations

Abstract

The chlorinated phenoxy acid herbicides (CPAHs) appears to have similar pharmacokinetics. They are rapidly and almost completely absorbed from an oral dose. They distribute to other tissues and are highly protein-bound in the plasma. The CPAHs are rapidly eliminated unchanged in the urine by an active process in the kidneys. Increasing doses apparently influence absorption, metabolism, distribution and elimination of the CPAHs so that biological effects are increased. Combinations of CPAHs are likely to result in additive or potentiated biological effects. Data suggest that CPAH toxicosis may be alleviated by treatment with fluids and bicarbonate to increase urinary pH and volume, thereby increasing excretion.

Original languageEnglish (US)
Pages (from-to)121-125
Number of pages5
JournalVeterinary and Human Toxicology
Volume31
Issue number2
StatePublished - Jan 1 1989

All Science Journal Classification (ASJC) codes

  • Toxicology
  • veterinary(all)
  • Health, Toxicology and Mutagenesis

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