The PPARα-leukotriene B4 pathway to inflammation control

Pallavi R. Devchand, Hansjörg Keller, Jeffrey M. Peters, Manuel Vazquez, Frank J. Gonzalez, Walter Wahli

Research output: Contribution to journalArticlepeer-review

1186 Scopus citations

Abstract

Inflammation is a local immune response to 'foreign' molecules, infection and injury. Leukotriene B4, a potent chemotactic agent that initiates, coordinates, sustains and amplifies the inflammatory response, is shown to be an activating ligand for the transcription factor PPARα. Because PPARα regulates the oxidative degradation of fatty acids and their derivatives, like this lipid mediator, a feedback mechanism is proposed that controls the duration of an inflammatory response and the clearance of leukotriene B4 in the liver. Thus PPARα offers a new route to the development of anti- or pro-inflammatory reagents.

Original languageEnglish (US)
Pages (from-to)39-43
Number of pages5
JournalNature
Volume384
Issue number6604
DOIs
StatePublished - Nov 7 1996

All Science Journal Classification (ASJC) codes

  • General

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