The prognostic significance of Ki-67 labeling indices for oligodendrogliomas

Stephen W. Coons, Peter C. Johnson, Dennis Keith Pearl

Research output: Contribution to journalArticlepeer-review

100 Scopus citations

Abstract

OBJECTIVE: The prognostic significance of quantitative measurement of tumor proliferative activity was evaluated for oligodendroglial tumors. METHODS: Ki-67/MIB-1 immunochemistry was used to measure proliferative activity in 81 oligodendrogliomas and oligoastrocytomas. The relationships among survival, proliferation, histological features, and clinical variables were evaluated using a Cox proportional hazards analysis. RESULTS: After stratifying by histological grade and adjusting for age at diagnosis, there was a significant association between the Ki-67/MIB-1 labeling index (LI) (percentage of positive cells) and survival (P = 0.04). This association was illustrated further by the significantly different survival of two groups based on LI ranges of less than or equal to 5 and greater than 5 (P < 0.0001). CONCLUSION: The poor correlation between mitotic figures and survival in oligodendrogliomas that has been reported previously emphasizes the need for an accurate method to measure proliferative activity. Our study demonstrated the usefulness of the Ki-67/MIB-1 LI and demonstrated that LI ranges can be defined for clinical application.

Original languageEnglish (US)
Pages (from-to)878-885
Number of pages8
JournalNeurosurgery
Volume41
Issue number4
DOIs
StatePublished - Oct 1 1997

All Science Journal Classification (ASJC) codes

  • Surgery
  • Clinical Neurology

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