The proteasome regulates the UV-induced activation of the AP-1-like transcription factor Gcn4

M. L. Stitzel, R. Durso, J. C. Reese

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

The proteasome is well known for its regulation of the cell cycle and degradation of mis-folded proteins, yet many of its functions are still unknown. We show that RPN11, a gene encoding a subunit of the regulatory cap of the proteasome, is required for UV-stimulated activation of Gcn4p target genes, but is dispensable for their activation by the general control pathway. We provide evidence that RPN11 functions downstream of RAS2, and show that mutation of two additional proteasome subunits results in identical phenotypes. Our analysis defines a novel function of the proteasome: regulation of the RAS- and AP-1 transcription factor-dependent UV resistance pathway.

Original languageEnglish (US)
Pages (from-to)128-133
Number of pages6
JournalGenes and Development
Volume15
Issue number2
DOIs
StatePublished - Jan 15 2001

All Science Journal Classification (ASJC) codes

  • Genetics
  • Developmental Biology

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