The purinosome, a multi-protein complex involved in the de novo biosynthesis of purines in humans

Hong Zhao, Jarrod B. French, Ye Fang, Stephen J. Benkovic

Research output: Contribution to journalArticle

44 Scopus citations

Abstract

Purine nucleotides are ubiquitous molecules that play vital roles in all kingdoms of life, not only as components of nucleic acids, but also participating in signaling and energy storage. Cellular pools of purines are maintained by the tight control of several complementary and sometimes competing processes including de novo biosynthesis, salvage and catabolism of nucleotides. While great strides have been made over the past sixty years in understanding the biosynthesis of purines, we are experiencing a renaissance in this field. In this feature article we discuss the most recent discoveries relating to purine biosynthesis, with particular emphasis upon the dynamic multi-protein complex called the purinosome. In particular we highlight advances made towards understanding the assembly, control and function of this protein complex and the attempts made to exploit this knowledge for drug discovery.

Original languageEnglish (US)
Pages (from-to)4444-4452
Number of pages9
JournalChemical Communications
Volume49
Issue number40
DOIs
StatePublished - May 6 2013

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Fingerprint Dive into the research topics of 'The purinosome, a multi-protein complex involved in the de novo biosynthesis of purines in humans'. Together they form a unique fingerprint.

  • Cite this