The receptor-mediated, short-term activation of tyrosine hydroxylase in organ cultures of rat superior cervical ganglia

Tom Lloyd, Paula Montgomery, Gordon Guroff

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Tyrosine hydroxylation, measured in situ in superior cervical ganglia from neonatal rats, is increased two-fold by the addition of carbachol. This increase occurs within one hour and is not due to the synthesis of new enzyme protein, nor to a direct effect of carbachol on the enzyme. The stimulation is blocked by atropine, but not by hexamethonium. This stimulation represents the first report of a receptor-mediated short-term action on this rate-limiting enzyme.

Original languageEnglish (US)
Pages (from-to)1058-1062
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume86
Issue number4
DOIs
StatePublished - Feb 28 1979

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Superior Cervical Ganglion
Organ Culture Techniques
Tyrosine 3-Monooxygenase
Rats
Chemical activation
Carbachol
Enzymes
Hexamethonium
Hydroxylation
Atropine
Tyrosine
Proteins

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

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The receptor-mediated, short-term activation of tyrosine hydroxylase in organ cultures of rat superior cervical ganglia. / Lloyd, Tom; Montgomery, Paula; Guroff, Gordon.

In: Biochemical and Biophysical Research Communications, Vol. 86, No. 4, 28.02.1979, p. 1058-1062.

Research output: Contribution to journalArticle

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AU - Guroff, Gordon

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