Tyrosine hydroxylation, measured in situ in superior cervical ganglia from neonatal rats, is increased two-fold by the addition of carbachol. This increase occurs within one hour and is not due to the synthesis of new enzyme protein, nor to a direct effect of carbachol on the enzyme. The stimulation is blocked by atropine, but not by hexamethonium. This stimulation represents the first report of a receptor-mediated short-term action on this rate-limiting enzyme.
|Original language||English (US)|
|Number of pages||5|
|Journal||Biochemical and Biophysical Research Communications|
|State||Published - Feb 28 1979|
All Science Journal Classification (ASJC) codes
- Molecular Biology
- Cell Biology