The Regulation of Mitochondrial Replacement Techniques around the World

I. Glenn Cohen, Eli Y. Adashi, Sara Gerke, Ceacutesar Palacios-Gonzaacutelez, Vardit Ravitsky

    Research output: Contribution to journalReview articlepeer-review

    7 Scopus citations


    Mitochondrial replacement techniques (MRTs, also referred to as mitochondrial replacement therapies) have given hope to many women who wish to have genetically related children but have mitochondrial DNA mutations in their eggs. MRTs have also spurred deep ethical disagreements and led to different regulatory approaches worldwide. In this review, we discuss the current regulation of MRTs across several countries. After discussing the basics of the science, we describe the current law and policy directions in seven countries: The United Kingdom, the United States, Canada, Australia, Germany, Israel, and Singapore. We also discuss the emerging phenomenon of medical tourism (also called medical travel) for MRTs to places like Greece, Spain, Mexico, and Ukraine. We then pull out some key findings regarding similarities and differences in regulatory approaches around the world.

    Original languageEnglish (US)
    Pages (from-to)565-586
    Number of pages22
    JournalAnnual Review of Genomics and Human Genetics
    StatePublished - Aug 31 2020

    All Science Journal Classification (ASJC) codes

    • Molecular Biology
    • Genetics
    • Genetics(clinical)

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