The Regulation of Pathways of Inflammation and Resolution in Immune Cells and Cancer Stem Cells by Selenium

Bastihalli T. Diwakar, Arvind M. Korwar, Robert F. Paulson, K. Sandeep Prabhu

Research output: Chapter in Book/Report/Conference proceedingChapter

10 Scopus citations

Abstract

Cancer is a complex disease where cancer stem cells (CSCs) maintain unlimited replicative potential, but evade chemotherapy drugs through cellular quiescence. CSCs are able to give rise to bulk tumor cells that have the capability to override antiproliferative signals and evade apoptosis. Numerous pathways are dysregulated in tumor cells, where increased levels of prooxidant reactive oxygen and nitrogen species can lead to localized inflammation to exacerbate all three stages of tumorigenesis: initiation, progression, and metastasis. Modulation of cellular metabolism in tumor cells as well as immune cells in the tumor microenvironment (TME) can impact inflammatory networks. Altering these pathways can potentially serve as a portal for therapy. It is well known that selenium, through selenoproteins, modulates inflammatory pathways in addition to regulating redox homeostasis in cells. Therefore, selenium has the potential to impact the interaction between tumor cells, CSCs, and immune cells. In the sections later, we review the current status of knowledge regarding this interaction, with reference to leukemia stem cells, and the importance of selenium-dependent regulation of inflammation as a potential mechanism to affect the TME and tumor cell survival.

Original languageEnglish (US)
Title of host publicationAdvances in Cancer Research
PublisherAcademic Press Inc.
Pages153-172
Number of pages20
DOIs
StatePublished - 2017

Publication series

NameAdvances in Cancer Research
Volume136
ISSN (Print)0065-230X
ISSN (Electronic)2162-5557

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'The Regulation of Pathways of Inflammation and Resolution in Immune Cells and Cancer Stem Cells by Selenium'. Together they form a unique fingerprint.

  • Cite this

    Diwakar, B. T., Korwar, A. M., Paulson, R. F., & Prabhu, K. S. (2017). The Regulation of Pathways of Inflammation and Resolution in Immune Cells and Cancer Stem Cells by Selenium. In Advances in Cancer Research (pp. 153-172). (Advances in Cancer Research; Vol. 136). Academic Press Inc.. https://doi.org/10.1016/bs.acr.2017.07.003