The Regulation of Pathways of Inflammation and Resolution in Immune Cells and Cancer Stem Cells by Selenium

Bastihalli T. Diwakar, Arvind M. Korwar, Robert Paulson, Kumble Sandeep Prabhu

Research output: Chapter in Book/Report/Conference proceedingChapter

7 Citations (Scopus)

Abstract

Cancer is a complex disease where cancer stem cells (CSCs) maintain unlimited replicative potential, but evade chemotherapy drugs through cellular quiescence. CSCs are able to give rise to bulk tumor cells that have the capability to override antiproliferative signals and evade apoptosis. Numerous pathways are dysregulated in tumor cells, where increased levels of prooxidant reactive oxygen and nitrogen species can lead to localized inflammation to exacerbate all three stages of tumorigenesis: initiation, progression, and metastasis. Modulation of cellular metabolism in tumor cells as well as immune cells in the tumor microenvironment (TME) can impact inflammatory networks. Altering these pathways can potentially serve as a portal for therapy. It is well known that selenium, through selenoproteins, modulates inflammatory pathways in addition to regulating redox homeostasis in cells. Therefore, selenium has the potential to impact the interaction between tumor cells, CSCs, and immune cells. In the sections later, we review the current status of knowledge regarding this interaction, with reference to leukemia stem cells, and the importance of selenium-dependent regulation of inflammation as a potential mechanism to affect the TME and tumor cell survival.

Original languageEnglish (US)
Title of host publicationAdvances in Cancer Research
PublisherAcademic Press Inc.
Pages153-172
Number of pages20
DOIs
StatePublished - Jan 1 2017

Publication series

NameAdvances in Cancer Research
Volume136
ISSN (Print)0065-230X
ISSN (Electronic)2162-5557

Fingerprint

Neoplastic Stem Cells
Selenium
Inflammation
Neoplasms
Tumor Microenvironment
Selenoproteins
Reactive Nitrogen Species
Oxidation-Reduction
Reactive Oxygen Species
Cell Survival
Carcinogenesis
Leukemia
Homeostasis
Stem Cells
Apoptosis
Neoplasm Metastasis
Drug Therapy
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Diwakar, B. T., Korwar, A. M., Paulson, R., & Prabhu, K. S. (2017). The Regulation of Pathways of Inflammation and Resolution in Immune Cells and Cancer Stem Cells by Selenium. In Advances in Cancer Research (pp. 153-172). (Advances in Cancer Research; Vol. 136). Academic Press Inc.. https://doi.org/10.1016/bs.acr.2017.07.003
Diwakar, Bastihalli T. ; Korwar, Arvind M. ; Paulson, Robert ; Prabhu, Kumble Sandeep. / The Regulation of Pathways of Inflammation and Resolution in Immune Cells and Cancer Stem Cells by Selenium. Advances in Cancer Research. Academic Press Inc., 2017. pp. 153-172 (Advances in Cancer Research).
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Diwakar, BT, Korwar, AM, Paulson, R & Prabhu, KS 2017, The Regulation of Pathways of Inflammation and Resolution in Immune Cells and Cancer Stem Cells by Selenium. in Advances in Cancer Research. Advances in Cancer Research, vol. 136, Academic Press Inc., pp. 153-172. https://doi.org/10.1016/bs.acr.2017.07.003

The Regulation of Pathways of Inflammation and Resolution in Immune Cells and Cancer Stem Cells by Selenium. / Diwakar, Bastihalli T.; Korwar, Arvind M.; Paulson, Robert; Prabhu, Kumble Sandeep.

Advances in Cancer Research. Academic Press Inc., 2017. p. 153-172 (Advances in Cancer Research; Vol. 136).

Research output: Chapter in Book/Report/Conference proceedingChapter

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Diwakar BT, Korwar AM, Paulson R, Prabhu KS. The Regulation of Pathways of Inflammation and Resolution in Immune Cells and Cancer Stem Cells by Selenium. In Advances in Cancer Research. Academic Press Inc. 2017. p. 153-172. (Advances in Cancer Research). https://doi.org/10.1016/bs.acr.2017.07.003