The regulatory roles of ROCK and MRCK kinases in the plasticity of cancer cell migration

Research output: Contribution to journalReview article

20 Scopus citations

Abstract

Metastatic cancer cells show great plasticity in their migratory mechanisms. In this review we briefly describe the signal transduction pathways associated with the ROCK and MRCK kinases and their roles in cancer cell migration and in its plasticity. With respect to therapeutic strategies targeting metastatic cancers, selectively blocking a single target, such as ROCK or MRCK, can induce alternate modes of cancer cell migration (i.e. plasticity) making the treatment ineffective. To address the problem of plasticity, we will discuss the strategy of simultaneous targeting of both ROCK and MRCK as an effective anti-metastatic therapeutics.

Original languageEnglish (US)
Pages (from-to)185-196
Number of pages12
JournalCancer Letters
Volume361
Issue number2
DOIs
StatePublished - Jun 1 2015

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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