The regulatory roles of ROCK and MRCK kinases in the plasticity of cancer cell migration

Research output: Contribution to journalShort survey

14 Citations (Scopus)

Abstract

Metastatic cancer cells show great plasticity in their migratory mechanisms. In this review we briefly describe the signal transduction pathways associated with the ROCK and MRCK kinases and their roles in cancer cell migration and in its plasticity. With respect to therapeutic strategies targeting metastatic cancers, selectively blocking a single target, such as ROCK or MRCK, can induce alternate modes of cancer cell migration (i.e. plasticity) making the treatment ineffective. To address the problem of plasticity, we will discuss the strategy of simultaneous targeting of both ROCK and MRCK as an effective anti-metastatic therapeutics.

Original languageEnglish (US)
Pages (from-to)185-196
Number of pages12
JournalCancer Letters
Volume361
Issue number2
DOIs
StatePublished - Jun 1 2015

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Cell Movement
Phosphotransferases
Neoplasms
Signal Transduction
Therapeutics

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

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title = "The regulatory roles of ROCK and MRCK kinases in the plasticity of cancer cell migration",
abstract = "Metastatic cancer cells show great plasticity in their migratory mechanisms. In this review we briefly describe the signal transduction pathways associated with the ROCK and MRCK kinases and their roles in cancer cell migration and in its plasticity. With respect to therapeutic strategies targeting metastatic cancers, selectively blocking a single target, such as ROCK or MRCK, can induce alternate modes of cancer cell migration (i.e. plasticity) making the treatment ineffective. To address the problem of plasticity, we will discuss the strategy of simultaneous targeting of both ROCK and MRCK as an effective anti-metastatic therapeutics.",
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The regulatory roles of ROCK and MRCK kinases in the plasticity of cancer cell migration. / Kale, Vijay Pralhad; Hengst, Jeremy; Desai, Dhimant; Amin, Shantu; Yun, Jong.

In: Cancer Letters, Vol. 361, No. 2, 01.06.2015, p. 185-196.

Research output: Contribution to journalShort survey

TY - JOUR

T1 - The regulatory roles of ROCK and MRCK kinases in the plasticity of cancer cell migration

AU - Kale, Vijay Pralhad

AU - Hengst, Jeremy

AU - Desai, Dhimant

AU - Amin, Shantu

AU - Yun, Jong

PY - 2015/6/1

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AB - Metastatic cancer cells show great plasticity in their migratory mechanisms. In this review we briefly describe the signal transduction pathways associated with the ROCK and MRCK kinases and their roles in cancer cell migration and in its plasticity. With respect to therapeutic strategies targeting metastatic cancers, selectively blocking a single target, such as ROCK or MRCK, can induce alternate modes of cancer cell migration (i.e. plasticity) making the treatment ineffective. To address the problem of plasticity, we will discuss the strategy of simultaneous targeting of both ROCK and MRCK as an effective anti-metastatic therapeutics.

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