Abstract
Metastatic cancer cells show great plasticity in their migratory mechanisms. In this review we briefly describe the signal transduction pathways associated with the ROCK and MRCK kinases and their roles in cancer cell migration and in its plasticity. With respect to therapeutic strategies targeting metastatic cancers, selectively blocking a single target, such as ROCK or MRCK, can induce alternate modes of cancer cell migration (i.e. plasticity) making the treatment ineffective. To address the problem of plasticity, we will discuss the strategy of simultaneous targeting of both ROCK and MRCK as an effective anti-metastatic therapeutics.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 185-196 |
| Number of pages | 12 |
| Journal | Cancer Letters |
| Volume | 361 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jun 1 2015 |
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All Science Journal Classification (ASJC) codes
- Oncology
- Cancer Research
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The regulatory roles of ROCK and MRCK kinases in the plasticity of cancer cell migration. / Kale, Vijay Pralhad; Hengst, Jeremy; Desai, Dhimant; Amin, Shantu; Yun, Jong.
In: Cancer Letters, Vol. 361, No. 2, 01.06.2015, p. 185-196.Research output: Contribution to journal › Short survey
TY - JOUR
T1 - The regulatory roles of ROCK and MRCK kinases in the plasticity of cancer cell migration
AU - Kale, Vijay Pralhad
AU - Hengst, Jeremy
AU - Desai, Dhimant
AU - Amin, Shantu
AU - Yun, Jong
PY - 2015/6/1
Y1 - 2015/6/1
N2 - Metastatic cancer cells show great plasticity in their migratory mechanisms. In this review we briefly describe the signal transduction pathways associated with the ROCK and MRCK kinases and their roles in cancer cell migration and in its plasticity. With respect to therapeutic strategies targeting metastatic cancers, selectively blocking a single target, such as ROCK or MRCK, can induce alternate modes of cancer cell migration (i.e. plasticity) making the treatment ineffective. To address the problem of plasticity, we will discuss the strategy of simultaneous targeting of both ROCK and MRCK as an effective anti-metastatic therapeutics.
AB - Metastatic cancer cells show great plasticity in their migratory mechanisms. In this review we briefly describe the signal transduction pathways associated with the ROCK and MRCK kinases and their roles in cancer cell migration and in its plasticity. With respect to therapeutic strategies targeting metastatic cancers, selectively blocking a single target, such as ROCK or MRCK, can induce alternate modes of cancer cell migration (i.e. plasticity) making the treatment ineffective. To address the problem of plasticity, we will discuss the strategy of simultaneous targeting of both ROCK and MRCK as an effective anti-metastatic therapeutics.
UR - http://www.scopus.com/inward/record.url?scp=84926089061&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84926089061&partnerID=8YFLogxK
U2 - 10.1016/j.canlet.2015.03.017
DO - 10.1016/j.canlet.2015.03.017
M3 - Short survey
C2 - 25796438
AN - SCOPUS:84926089061
VL - 361
SP - 185
EP - 196
JO - Cancer Letters
JF - Cancer Letters
SN - 0304-3835
IS - 2
ER -