The regulatory roles of ROCK and MRCK kinases in the plasticity of cancer cell migration

Vijay Pralhad Kale; Jeremy A. Hengst; Dhimant H. Desai; Shantu G. Amin; Jong K. Yun

doi:10.1016/j.canlet.2015.03.017

The regulatory roles of ROCK and MRCK kinases in the plasticity of cancer cell migration

Vijay Pralhad Kale, Jeremy A. Hengst, Dhimant H. Desai, Shantu G. Amin, Jong K. Yun

Research output: Contribution to journal › Review article › peer-review

28 Scopus citations

Abstract

Metastatic cancer cells show great plasticity in their migratory mechanisms. In this review we briefly describe the signal transduction pathways associated with the ROCK and MRCK kinases and their roles in cancer cell migration and in its plasticity. With respect to therapeutic strategies targeting metastatic cancers, selectively blocking a single target, such as ROCK or MRCK, can induce alternate modes of cancer cell migration (i.e. plasticity) making the treatment ineffective. To address the problem of plasticity, we will discuss the strategy of simultaneous targeting of both ROCK and MRCK as an effective anti-metastatic therapeutics.

Original language	English (US)
Pages (from-to)	185-196
Number of pages	12
Journal	Cancer Letters
Volume	361
Issue number	2
DOIs	https://doi.org/10.1016/j.canlet.2015.03.017
State	Published - Jun 1 2015

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.canlet.2015.03.017

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title = "The regulatory roles of ROCK and MRCK kinases in the plasticity of cancer cell migration",

abstract = "Metastatic cancer cells show great plasticity in their migratory mechanisms. In this review we briefly describe the signal transduction pathways associated with the ROCK and MRCK kinases and their roles in cancer cell migration and in its plasticity. With respect to therapeutic strategies targeting metastatic cancers, selectively blocking a single target, such as ROCK or MRCK, can induce alternate modes of cancer cell migration (i.e. plasticity) making the treatment ineffective. To address the problem of plasticity, we will discuss the strategy of simultaneous targeting of both ROCK and MRCK as an effective anti-metastatic therapeutics.",

author = "Kale, {Vijay Pralhad} and Hengst, {Jeremy A.} and Desai, {Dhimant H.} and Amin, {Shantu G.} and Yun, {Jong K.}",

note = "Funding Information: We thank Department of Pharmacology, Penn State Hershey Cancer Institute , and Jake Gittlen Laboratories for Cancer Research for financial support (JKY) for this project. Publisher Copyright: {\textcopyright} 2015 Elsevier Ireland Ltd.",

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doi = "10.1016/j.canlet.2015.03.017",

language = "English (US)",

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T1 - The regulatory roles of ROCK and MRCK kinases in the plasticity of cancer cell migration

AU - Kale, Vijay Pralhad

AU - Hengst, Jeremy A.

AU - Desai, Dhimant H.

AU - Amin, Shantu G.

AU - Yun, Jong K.

N1 - Funding Information: We thank Department of Pharmacology, Penn State Hershey Cancer Institute , and Jake Gittlen Laboratories for Cancer Research for financial support (JKY) for this project. Publisher Copyright: © 2015 Elsevier Ireland Ltd.

PY - 2015/6/1

Y1 - 2015/6/1

N2 - Metastatic cancer cells show great plasticity in their migratory mechanisms. In this review we briefly describe the signal transduction pathways associated with the ROCK and MRCK kinases and their roles in cancer cell migration and in its plasticity. With respect to therapeutic strategies targeting metastatic cancers, selectively blocking a single target, such as ROCK or MRCK, can induce alternate modes of cancer cell migration (i.e. plasticity) making the treatment ineffective. To address the problem of plasticity, we will discuss the strategy of simultaneous targeting of both ROCK and MRCK as an effective anti-metastatic therapeutics.

AB - Metastatic cancer cells show great plasticity in their migratory mechanisms. In this review we briefly describe the signal transduction pathways associated with the ROCK and MRCK kinases and their roles in cancer cell migration and in its plasticity. With respect to therapeutic strategies targeting metastatic cancers, selectively blocking a single target, such as ROCK or MRCK, can induce alternate modes of cancer cell migration (i.e. plasticity) making the treatment ineffective. To address the problem of plasticity, we will discuss the strategy of simultaneous targeting of both ROCK and MRCK as an effective anti-metastatic therapeutics.

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The regulatory roles of ROCK and MRCK kinases in the plasticity of cancer cell migration

Abstract

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