The reinforcing properties of salsolinol in the ventral tegmental area: Evidence for regional heterogeneity and the involvement of serotonin and dopamine

Zachary A. Rodd, Scott M. Oster, Zheng-Ming Ding, Jamie E. Toalston, Gerald Deehan, Richard L. Bell, Ting Kai Li, William J. McBride

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Background: Salsolinol (SAL), the condensation product of acetaldehyde and dopamine, may be a factor contributing to alcohol abuse. Previous research indicated that both ethanol and acetaldehyde are self-administered into the posterior ventral tegmental area (VTA). The current study examined SAL self-infusions into the VTA, and determined the involvement of dopamine neurons and 5-HT3 receptors in this process. Methods: The intracranial self-administration technique was used to determine the self-infusion of SAL into the VTA of adult, male Wistar rats. The rats were placed in 2-lever (active and inactive) experimental chambers, and allowed to respond for the self-infusion of 0, 0.03, 0.1, 0.3, 1.0 or 3.0 μM SAL into the posterior or anterior VTA. In a second experiment, rats self-administered 0.3 μM SAL for the initial 4 sessions, co-administered SAL with ICS-205,930 (a 5-HT3 receptor antagonist) or quinpirole (a D2,3 receptor agonist) for sessions 5 and 6, and then only 0.3 μM SAL for session 7. Results: Wistar rats, given 0.03 to 0.3 μM SAL, received more infusions per session than did the group given artificial cerebrospinal fluid (aCSF) alone (e.g., 41 infusions for 0.1 μM SAL versus 9 infusions for the aCSF group), and responded more on the active than inactive lever. These effects were observed in the posterior but not in anterior VTA. Co-infusion of 100 μM ICS-205,930, or quinpirole significantly reduced self-infusions and active lever responding. Conclusions: SAL produces reinforcing effects in the posterior VTA of Wistar rats, and these effects are mediated by activation of DA neurons and local 5-HT3 receptors.

Original languageEnglish (US)
Pages (from-to)230-239
Number of pages10
JournalAlcoholism: Clinical and Experimental Research
Volume32
Issue number2
DOIs
StatePublished - Feb 1 2008

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Ventral Tegmental Area
Dopamine
Serotonin
tropisetron
Rats
Receptors, Serotonin, 5-HT3
Quinpirole
Cerebrospinal fluid
Wistar Rats
Acetaldehyde
Neurons
Cerebrospinal Fluid
salsolinol
Serotonin 5-HT3 Receptor Antagonists
Self Administration
Dopaminergic Neurons
Alcoholism
Condensation
Ethanol
Chemical activation

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Toxicology
  • Psychiatry and Mental health

Cite this

Rodd, Zachary A. ; Oster, Scott M. ; Ding, Zheng-Ming ; Toalston, Jamie E. ; Deehan, Gerald ; Bell, Richard L. ; Li, Ting Kai ; McBride, William J. / The reinforcing properties of salsolinol in the ventral tegmental area : Evidence for regional heterogeneity and the involvement of serotonin and dopamine. In: Alcoholism: Clinical and Experimental Research. 2008 ; Vol. 32, No. 2. pp. 230-239.
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title = "The reinforcing properties of salsolinol in the ventral tegmental area: Evidence for regional heterogeneity and the involvement of serotonin and dopamine",
abstract = "Background: Salsolinol (SAL), the condensation product of acetaldehyde and dopamine, may be a factor contributing to alcohol abuse. Previous research indicated that both ethanol and acetaldehyde are self-administered into the posterior ventral tegmental area (VTA). The current study examined SAL self-infusions into the VTA, and determined the involvement of dopamine neurons and 5-HT3 receptors in this process. Methods: The intracranial self-administration technique was used to determine the self-infusion of SAL into the VTA of adult, male Wistar rats. The rats were placed in 2-lever (active and inactive) experimental chambers, and allowed to respond for the self-infusion of 0, 0.03, 0.1, 0.3, 1.0 or 3.0 μM SAL into the posterior or anterior VTA. In a second experiment, rats self-administered 0.3 μM SAL for the initial 4 sessions, co-administered SAL with ICS-205,930 (a 5-HT3 receptor antagonist) or quinpirole (a D2,3 receptor agonist) for sessions 5 and 6, and then only 0.3 μM SAL for session 7. Results: Wistar rats, given 0.03 to 0.3 μM SAL, received more infusions per session than did the group given artificial cerebrospinal fluid (aCSF) alone (e.g., 41 infusions for 0.1 μM SAL versus 9 infusions for the aCSF group), and responded more on the active than inactive lever. These effects were observed in the posterior but not in anterior VTA. Co-infusion of 100 μM ICS-205,930, or quinpirole significantly reduced self-infusions and active lever responding. Conclusions: SAL produces reinforcing effects in the posterior VTA of Wistar rats, and these effects are mediated by activation of DA neurons and local 5-HT3 receptors.",
author = "Rodd, {Zachary A.} and Oster, {Scott M.} and Zheng-Ming Ding and Toalston, {Jamie E.} and Gerald Deehan and Bell, {Richard L.} and Li, {Ting Kai} and McBride, {William J.}",
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The reinforcing properties of salsolinol in the ventral tegmental area : Evidence for regional heterogeneity and the involvement of serotonin and dopamine. / Rodd, Zachary A.; Oster, Scott M.; Ding, Zheng-Ming; Toalston, Jamie E.; Deehan, Gerald; Bell, Richard L.; Li, Ting Kai; McBride, William J.

In: Alcoholism: Clinical and Experimental Research, Vol. 32, No. 2, 01.02.2008, p. 230-239.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The reinforcing properties of salsolinol in the ventral tegmental area

T2 - Evidence for regional heterogeneity and the involvement of serotonin and dopamine

AU - Rodd, Zachary A.

AU - Oster, Scott M.

AU - Ding, Zheng-Ming

AU - Toalston, Jamie E.

AU - Deehan, Gerald

AU - Bell, Richard L.

AU - Li, Ting Kai

AU - McBride, William J.

PY - 2008/2/1

Y1 - 2008/2/1

N2 - Background: Salsolinol (SAL), the condensation product of acetaldehyde and dopamine, may be a factor contributing to alcohol abuse. Previous research indicated that both ethanol and acetaldehyde are self-administered into the posterior ventral tegmental area (VTA). The current study examined SAL self-infusions into the VTA, and determined the involvement of dopamine neurons and 5-HT3 receptors in this process. Methods: The intracranial self-administration technique was used to determine the self-infusion of SAL into the VTA of adult, male Wistar rats. The rats were placed in 2-lever (active and inactive) experimental chambers, and allowed to respond for the self-infusion of 0, 0.03, 0.1, 0.3, 1.0 or 3.0 μM SAL into the posterior or anterior VTA. In a second experiment, rats self-administered 0.3 μM SAL for the initial 4 sessions, co-administered SAL with ICS-205,930 (a 5-HT3 receptor antagonist) or quinpirole (a D2,3 receptor agonist) for sessions 5 and 6, and then only 0.3 μM SAL for session 7. Results: Wistar rats, given 0.03 to 0.3 μM SAL, received more infusions per session than did the group given artificial cerebrospinal fluid (aCSF) alone (e.g., 41 infusions for 0.1 μM SAL versus 9 infusions for the aCSF group), and responded more on the active than inactive lever. These effects were observed in the posterior but not in anterior VTA. Co-infusion of 100 μM ICS-205,930, or quinpirole significantly reduced self-infusions and active lever responding. Conclusions: SAL produces reinforcing effects in the posterior VTA of Wistar rats, and these effects are mediated by activation of DA neurons and local 5-HT3 receptors.

AB - Background: Salsolinol (SAL), the condensation product of acetaldehyde and dopamine, may be a factor contributing to alcohol abuse. Previous research indicated that both ethanol and acetaldehyde are self-administered into the posterior ventral tegmental area (VTA). The current study examined SAL self-infusions into the VTA, and determined the involvement of dopamine neurons and 5-HT3 receptors in this process. Methods: The intracranial self-administration technique was used to determine the self-infusion of SAL into the VTA of adult, male Wistar rats. The rats were placed in 2-lever (active and inactive) experimental chambers, and allowed to respond for the self-infusion of 0, 0.03, 0.1, 0.3, 1.0 or 3.0 μM SAL into the posterior or anterior VTA. In a second experiment, rats self-administered 0.3 μM SAL for the initial 4 sessions, co-administered SAL with ICS-205,930 (a 5-HT3 receptor antagonist) or quinpirole (a D2,3 receptor agonist) for sessions 5 and 6, and then only 0.3 μM SAL for session 7. Results: Wistar rats, given 0.03 to 0.3 μM SAL, received more infusions per session than did the group given artificial cerebrospinal fluid (aCSF) alone (e.g., 41 infusions for 0.1 μM SAL versus 9 infusions for the aCSF group), and responded more on the active than inactive lever. These effects were observed in the posterior but not in anterior VTA. Co-infusion of 100 μM ICS-205,930, or quinpirole significantly reduced self-infusions and active lever responding. Conclusions: SAL produces reinforcing effects in the posterior VTA of Wistar rats, and these effects are mediated by activation of DA neurons and local 5-HT3 receptors.

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