The relation between the divergence of sequence and structure in proteins.

C. Chothia, A. M. Lesk

Research output: Contribution to journalArticlepeer-review

1886 Scopus citations

Abstract

Homologous proteins have regions which retain the same general fold and regions where the folds differ. For pairs of distantly related proteins (residue identity approximately 20%), the regions with the same fold may comprise less than half of each molecule. The regions with the same general fold differ in structure by amounts that increase as the amino acid sequences diverge. The root mean square deviation in the positions of the main chain atoms, delta, is related to the fraction of mutated residues, H, by the expression: delta(A) = 0.40 e1.87H.

Original languageEnglish (US)
Pages (from-to)823-826
Number of pages4
JournalThe EMBO journal
Volume5
Issue number4
DOIs
StatePublished - Apr 1986

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Fingerprint Dive into the research topics of 'The relation between the divergence of sequence and structure in proteins.'. Together they form a unique fingerprint.

Cite this