The relationship between calcium intake and pregnancy-induced hypertension: Up-to-date evidence

JoséM M. Belizán, José Villar, John Repke

Research output: Contribution to journalArticle

138 Citations (Scopus)

Abstract

In 1980 we pointed to a relationship between calcium intake and pregnancy-induced hypertension. The original epidemiologic observations showed an inverse association between calcium intake and incidence of eclampsia after adjusting by several confounding factors. A series of recent randomized clinical trials have demonstrated a reduction in blood pressure with calcium supplementation in animals, in healthy and mildly hypertensive subjects, and in pregnant women. It is hypothesized that parathyroid hormone plays a role since it is affected by calcium intake and can partially regulate the concentration of free cytosolic ionized calcium, thus triggering smooth muscle contraction. Randomized clinical trials showing a reduction in the incidence of pregnancy-induced hypertension with calcium supplementation have not as yet been published. However, preliminary observations appear to support this hypothsis.

Original languageEnglish (US)
Pages (from-to)898-902
Number of pages5
JournalAmerican Journal of Obstetrics and Gynecology
Volume158
Issue number4
DOIs
StatePublished - Jan 1 1988

Fingerprint

Pregnancy Induced Hypertension
Calcium
Randomized Controlled Trials
Eclampsia
Incidence
Muscle Contraction
Parathyroid Hormone
Smooth Muscle
Pregnant Women
Blood Pressure

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynecology

Cite this

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The relationship between calcium intake and pregnancy-induced hypertension : Up-to-date evidence. / Belizán, JoséM M.; Villar, José; Repke, John.

In: American Journal of Obstetrics and Gynecology, Vol. 158, No. 4, 01.01.1988, p. 898-902.

Research output: Contribution to journalArticle

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