The relationship between parental depressive symptoms and offspring psychopathology

Evidence from a children-of-twins study and an adoption study

T. A. McAdams, F. V. Rijsdijk, Jenae Marie Neiderhiser, J. Narusyte, D. S. Shaw, M. N. Natsuaki, E. L. Spotts, J. M. Ganiban, David Reiss, L. D. Leve, P. Lichtenstein, T. C. Eley

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Background Parental depressive symptoms are associated with emotional and behavioural problems in offspring. However, genetically informative studies are needed to distinguish potential causal effects from genetic confounds, and longitudinal studies are required to distinguish parent-to-child effects from child-to-parent effects. Method We conducted cross-sectional analyses on a sample of Swedish twins and their adolescent offspring (n = 876 twin families), and longitudinal analyses on a US sample of children adopted at birth, their adoptive parents, and their birth mothers (n = 361 adoptive families). Depressive symptoms were measured in parents, and externalizing and internalizing problems measured in offspring. Structural equation models were fitted to the data. Results Results of model fitting suggest that associations between parental depressive symptoms and offspring internalizing and externalizing problems remain after accounting for genes shared between parent and child. Genetic transmission was not evident in the twin study but was evident in the adoption study. In the longitudinal adoption study child-to-parent effects were evident. Conclusions We interpret the results as demonstrating that associations between parental depressive symptoms and offspring emotional and behavioural problems are not solely attributable to shared genes, and that bidirectional effects may be present in intergenerational associations.

Original languageEnglish (US)
Pages (from-to)2583-2594
Number of pages12
JournalPsychological medicine
Volume45
Issue number12
DOIs
StatePublished - Sep 5 2015

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Twin Studies
Psychopathology
Depression
Longitudinal Studies
Parents
Parturition
Structural Models
Genes
Cross-Sectional Studies
Mothers

All Science Journal Classification (ASJC) codes

  • Applied Psychology
  • Psychiatry and Mental health

Cite this

McAdams, T. A. ; Rijsdijk, F. V. ; Neiderhiser, Jenae Marie ; Narusyte, J. ; Shaw, D. S. ; Natsuaki, M. N. ; Spotts, E. L. ; Ganiban, J. M. ; Reiss, David ; Leve, L. D. ; Lichtenstein, P. ; Eley, T. C. / The relationship between parental depressive symptoms and offspring psychopathology : Evidence from a children-of-twins study and an adoption study. In: Psychological medicine. 2015 ; Vol. 45, No. 12. pp. 2583-2594.
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abstract = "Background Parental depressive symptoms are associated with emotional and behavioural problems in offspring. However, genetically informative studies are needed to distinguish potential causal effects from genetic confounds, and longitudinal studies are required to distinguish parent-to-child effects from child-to-parent effects. Method We conducted cross-sectional analyses on a sample of Swedish twins and their adolescent offspring (n = 876 twin families), and longitudinal analyses on a US sample of children adopted at birth, their adoptive parents, and their birth mothers (n = 361 adoptive families). Depressive symptoms were measured in parents, and externalizing and internalizing problems measured in offspring. Structural equation models were fitted to the data. Results Results of model fitting suggest that associations between parental depressive symptoms and offspring internalizing and externalizing problems remain after accounting for genes shared between parent and child. Genetic transmission was not evident in the twin study but was evident in the adoption study. In the longitudinal adoption study child-to-parent effects were evident. Conclusions We interpret the results as demonstrating that associations between parental depressive symptoms and offspring emotional and behavioural problems are not solely attributable to shared genes, and that bidirectional effects may be present in intergenerational associations.",
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McAdams, TA, Rijsdijk, FV, Neiderhiser, JM, Narusyte, J, Shaw, DS, Natsuaki, MN, Spotts, EL, Ganiban, JM, Reiss, D, Leve, LD, Lichtenstein, P & Eley, TC 2015, 'The relationship between parental depressive symptoms and offspring psychopathology: Evidence from a children-of-twins study and an adoption study', Psychological medicine, vol. 45, no. 12, pp. 2583-2594. https://doi.org/10.1017/S0033291715000501

The relationship between parental depressive symptoms and offspring psychopathology : Evidence from a children-of-twins study and an adoption study. / McAdams, T. A.; Rijsdijk, F. V.; Neiderhiser, Jenae Marie; Narusyte, J.; Shaw, D. S.; Natsuaki, M. N.; Spotts, E. L.; Ganiban, J. M.; Reiss, David; Leve, L. D.; Lichtenstein, P.; Eley, T. C.

In: Psychological medicine, Vol. 45, No. 12, 05.09.2015, p. 2583-2594.

Research output: Contribution to journalArticle

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T1 - The relationship between parental depressive symptoms and offspring psychopathology

T2 - Evidence from a children-of-twins study and an adoption study

AU - McAdams, T. A.

AU - Rijsdijk, F. V.

AU - Neiderhiser, Jenae Marie

AU - Narusyte, J.

AU - Shaw, D. S.

AU - Natsuaki, M. N.

AU - Spotts, E. L.

AU - Ganiban, J. M.

AU - Reiss, David

AU - Leve, L. D.

AU - Lichtenstein, P.

AU - Eley, T. C.

PY - 2015/9/5

Y1 - 2015/9/5

N2 - Background Parental depressive symptoms are associated with emotional and behavioural problems in offspring. However, genetically informative studies are needed to distinguish potential causal effects from genetic confounds, and longitudinal studies are required to distinguish parent-to-child effects from child-to-parent effects. Method We conducted cross-sectional analyses on a sample of Swedish twins and their adolescent offspring (n = 876 twin families), and longitudinal analyses on a US sample of children adopted at birth, their adoptive parents, and their birth mothers (n = 361 adoptive families). Depressive symptoms were measured in parents, and externalizing and internalizing problems measured in offspring. Structural equation models were fitted to the data. Results Results of model fitting suggest that associations between parental depressive symptoms and offspring internalizing and externalizing problems remain after accounting for genes shared between parent and child. Genetic transmission was not evident in the twin study but was evident in the adoption study. In the longitudinal adoption study child-to-parent effects were evident. Conclusions We interpret the results as demonstrating that associations between parental depressive symptoms and offspring emotional and behavioural problems are not solely attributable to shared genes, and that bidirectional effects may be present in intergenerational associations.

AB - Background Parental depressive symptoms are associated with emotional and behavioural problems in offspring. However, genetically informative studies are needed to distinguish potential causal effects from genetic confounds, and longitudinal studies are required to distinguish parent-to-child effects from child-to-parent effects. Method We conducted cross-sectional analyses on a sample of Swedish twins and their adolescent offspring (n = 876 twin families), and longitudinal analyses on a US sample of children adopted at birth, their adoptive parents, and their birth mothers (n = 361 adoptive families). Depressive symptoms were measured in parents, and externalizing and internalizing problems measured in offspring. Structural equation models were fitted to the data. Results Results of model fitting suggest that associations between parental depressive symptoms and offspring internalizing and externalizing problems remain after accounting for genes shared between parent and child. Genetic transmission was not evident in the twin study but was evident in the adoption study. In the longitudinal adoption study child-to-parent effects were evident. Conclusions We interpret the results as demonstrating that associations between parental depressive symptoms and offspring emotional and behavioural problems are not solely attributable to shared genes, and that bidirectional effects may be present in intergenerational associations.

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