The relationships between the amount of spared tissue, percent signal change, and accuracy in semantic processing in aphasia

Jordyn A. Sims, Kushal Kapse, Peter Glynn, Chaleece Wyatt Sandberg, Yorghos Tripodis, Swathi Kiran

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Recovery from aphasia, loss of language following a cerebrovascular incident (stroke), is a complex process involving both left and right hemispheric regions. In our study, we analyzed the relationships between semantic processing behavioral data, lesion size and location, and percent signal change from functional magnetic resonance imaging (fMRI) data. This study included 14 persons with aphasia in the chronic stage of recovery (six or more months post stroke), along with normal controls, who performed semantic processing tasks of determining whether a written semantic feature matched a picture or whether two written words were related. Using region of interest (ROI) analysis, we found that left inferior frontal gyrus pars opercularis and pars triangularis, despite significant damage, were the only regions to correlate with behavioral accuracy. Additionally, bilateral frontal regions including superior frontal gyrus, middle frontal gyrus, and anterior cingulate appear to serve as an assistive network in the case of damage to traditional language regions that include inferior frontal gyrus, middle temporal gyrus, supramarginal gyrus, and angular gyrus. Right hemisphere posterior regions including right middle temporal gyrus, right supramarginal gyrus, and right angular gyrus are engaged in the case of extensive damage to left hemisphere language regions. Additionally, right inferior frontal gyrus pars orbitalis is presumed to serve a monitoring function. These results reinforce the importance of the left hemisphere in language processing in aphasia, and provide a framework for the relative importance of left and right language regions in the brain.

Original languageEnglish (US)
Pages (from-to)113-126
Number of pages14
JournalNeuropsychologia
Volume84
DOIs
StatePublished - Apr 1 2016

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Aphasia
Prefrontal Cortex
Parietal Lobe
Semantics
Language
Temporal Lobe
Stroke
Gyrus Cinguli
Magnetic Resonance Imaging
Brain
Broca Area

All Science Journal Classification (ASJC) codes

  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

Cite this

Sims, Jordyn A. ; Kapse, Kushal ; Glynn, Peter ; Sandberg, Chaleece Wyatt ; Tripodis, Yorghos ; Kiran, Swathi. / The relationships between the amount of spared tissue, percent signal change, and accuracy in semantic processing in aphasia. In: Neuropsychologia. 2016 ; Vol. 84. pp. 113-126.
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The relationships between the amount of spared tissue, percent signal change, and accuracy in semantic processing in aphasia. / Sims, Jordyn A.; Kapse, Kushal; Glynn, Peter; Sandberg, Chaleece Wyatt; Tripodis, Yorghos; Kiran, Swathi.

In: Neuropsychologia, Vol. 84, 01.04.2016, p. 113-126.

Research output: Contribution to journalArticle

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