The rich get richer: Brain injury elicits hyperconnectivity in core subnetworks

Frank Gerard Hillary, Sarah Rajtmajer, Cristina A. Roman, John D. Medaglia, Julia E. Slocomb-Dluzen, Vincent D. Calhoun, David Good, Glenn R. Wylie

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

There remains much unknown about how large-scale neural networks accommodate neurological disruption, such as moderate and severe traumatic brain injury (TBI). A primary goal in this study was to examine the alterations in network topology occurring during the first year of recovery following TBI. To do so we examined 21 individuals with moderate and severe TBI at 3 and 6 months after resolution of posttraumatic amnesia and 15 age- and education-matched healthy adults using functional MRI and graph theoretical analyses. There were two central hypotheses in this study: 1) physical disruption results in increased functional connectivity, or hyperconnectivity, and 2) hyperconnectivity occurs in regions typically observed to be the most highly connected cortical hubs, or the "rich club". The current findings generally support the hyperconnectivity hypothesis showing that during the first year of recovery after TBI, neural networks show increased connectivity, and this change is disproportionately represented in brain regions belonging to the brain's core subnetworks. The selective increases in connectivity observed here are consistent with the preferential attachment model underlying scale-free network development. This study is the largest of its kind and provides the unique opportunity to examine how neural systems adapt to significant neurological disruption during the first year after injury.

Original languageEnglish (US)
Article numbere104021
JournalPloS one
Volume9
Issue number8
DOIs
StatePublished - Aug 14 2014

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Brain Injuries
Brain
brain
neural networks
Amnesia
Neural networks
Recovery
Magnetic Resonance Imaging
Complex networks
Education
topology
Traumatic Brain Injury
education
Wounds and Injuries
Topology

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Hillary, F. G., Rajtmajer, S., Roman, C. A., Medaglia, J. D., Slocomb-Dluzen, J. E., Calhoun, V. D., ... Wylie, G. R. (2014). The rich get richer: Brain injury elicits hyperconnectivity in core subnetworks. PloS one, 9(8), [e104021]. https://doi.org/10.1371/journal.pone.0104021
Hillary, Frank Gerard ; Rajtmajer, Sarah ; Roman, Cristina A. ; Medaglia, John D. ; Slocomb-Dluzen, Julia E. ; Calhoun, Vincent D. ; Good, David ; Wylie, Glenn R. / The rich get richer : Brain injury elicits hyperconnectivity in core subnetworks. In: PloS one. 2014 ; Vol. 9, No. 8.
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The rich get richer : Brain injury elicits hyperconnectivity in core subnetworks. / Hillary, Frank Gerard; Rajtmajer, Sarah; Roman, Cristina A.; Medaglia, John D.; Slocomb-Dluzen, Julia E.; Calhoun, Vincent D.; Good, David; Wylie, Glenn R.

In: PloS one, Vol. 9, No. 8, e104021, 14.08.2014.

Research output: Contribution to journalArticle

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