The role of all-trans retinoic acid in the biology of FOXP3+ regulatory T cells

Zhong Min Liu; Kun Peng Wang; Jilin Ma; Song Guo Zheng

doi:10.1038/cmi.2014.133

The role of all-trans retinoic acid in the biology of FOXP3⁺ regulatory T cells

Zhong Min Liu, Kun Peng Wang, Jilin Ma, Song Guo Zheng

Department of Medicine

Research output: Contribution to journal › Review article › peer-review

58 Scopus citations

Abstract

Regulatory T (Treg) cells are necessary for immune system homeostasis and the prevention of autoimmune diseases. Foxp3 is specifically expressed in Treg cells and plays a key role in their differentiation and function. FOXP3⁺ Treg cells are consisted of naturally occurring, thymus-derived Treg (nTreg) and peripheral-induced Treg (iTreg) cells that may have different functional characteristics or synergistic roles. All-trans retinoic acid (atRA), a vitamin A metabolite, regulates a wide range of biological processes, including cell differentiation and proliferation. Recent studies demonstrated that atRA also regulates the differentiation of T helper (Th) cells and Treg cells. Moreover, atRA also sustains nTreg stability under inflammatory conditions. In this review, we summarize the significant progress of our understanding of the role(s) and mechanisms of atRA in Treg biology.

Original language	English (US)
Pages (from-to)	553-557
Number of pages	5
Journal	Cellular and Molecular Immunology
Volume	12
Issue number	5
DOIs	https://doi.org/10.1038/cmi.2014.133
State	Published - Sep 8 2015

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Immunology
Infectious Diseases

Access to Document

10.1038/cmi.2014.133

Fingerprint Dive into the research topics of 'The role of all-trans retinoic acid in the biology of FOXP3<sup>+</sup> regulatory T cells'. Together they form a unique fingerprint.

Cite this

@article{14f277dbb8f44b87829cc1b36a627c8e,

title = "The role of all-trans retinoic acid in the biology of FOXP3+ regulatory T cells",

abstract = "Regulatory T (Treg) cells are necessary for immune system homeostasis and the prevention of autoimmune diseases. Foxp3 is specifically expressed in Treg cells and plays a key role in their differentiation and function. FOXP3+ Treg cells are consisted of naturally occurring, thymus-derived Treg (nTreg) and peripheral-induced Treg (iTreg) cells that may have different functional characteristics or synergistic roles. All-trans retinoic acid (atRA), a vitamin A metabolite, regulates a wide range of biological processes, including cell differentiation and proliferation. Recent studies demonstrated that atRA also regulates the differentiation of T helper (Th) cells and Treg cells. Moreover, atRA also sustains nTreg stability under inflammatory conditions. In this review, we summarize the significant progress of our understanding of the role(s) and mechanisms of atRA in Treg biology.",

author = "Liu, {Zhong Min} and Wang, {Kun Peng} and Jilin Ma and {Guo Zheng}, Song",

year = "2015",

month = sep,

day = "8",

doi = "10.1038/cmi.2014.133",

language = "English (US)",

volume = "12",

pages = "553--557",

journal = "Cellular and Molecular Immunology",

issn = "1672-7681",

publisher = "Nature Publishing Group",

number = "5",

}

TY - JOUR

T1 - The role of all-trans retinoic acid in the biology of FOXP3+ regulatory T cells

AU - Liu, Zhong Min

AU - Wang, Kun Peng

AU - Ma, Jilin

AU - Guo Zheng, Song

PY - 2015/9/8

Y1 - 2015/9/8

N2 - Regulatory T (Treg) cells are necessary for immune system homeostasis and the prevention of autoimmune diseases. Foxp3 is specifically expressed in Treg cells and plays a key role in their differentiation and function. FOXP3+ Treg cells are consisted of naturally occurring, thymus-derived Treg (nTreg) and peripheral-induced Treg (iTreg) cells that may have different functional characteristics or synergistic roles. All-trans retinoic acid (atRA), a vitamin A metabolite, regulates a wide range of biological processes, including cell differentiation and proliferation. Recent studies demonstrated that atRA also regulates the differentiation of T helper (Th) cells and Treg cells. Moreover, atRA also sustains nTreg stability under inflammatory conditions. In this review, we summarize the significant progress of our understanding of the role(s) and mechanisms of atRA in Treg biology.

AB - Regulatory T (Treg) cells are necessary for immune system homeostasis and the prevention of autoimmune diseases. Foxp3 is specifically expressed in Treg cells and plays a key role in their differentiation and function. FOXP3+ Treg cells are consisted of naturally occurring, thymus-derived Treg (nTreg) and peripheral-induced Treg (iTreg) cells that may have different functional characteristics or synergistic roles. All-trans retinoic acid (atRA), a vitamin A metabolite, regulates a wide range of biological processes, including cell differentiation and proliferation. Recent studies demonstrated that atRA also regulates the differentiation of T helper (Th) cells and Treg cells. Moreover, atRA also sustains nTreg stability under inflammatory conditions. In this review, we summarize the significant progress of our understanding of the role(s) and mechanisms of atRA in Treg biology.

UR - http://www.scopus.com/inward/record.url?scp=84941125254&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84941125254&partnerID=8YFLogxK

U2 - 10.1038/cmi.2014.133

DO - 10.1038/cmi.2014.133

M3 - Review article

C2 - 25640656

AN - SCOPUS:84941125254

VL - 12

SP - 553

EP - 557

JO - Cellular and Molecular Immunology

JF - Cellular and Molecular Immunology

SN - 1672-7681

IS - 5

ER -