Abstract
Regulatory T (Treg) cells are necessary for immune system homeostasis and the prevention of autoimmune diseases. Foxp3 is specifically expressed in Treg cells and plays a key role in their differentiation and function. FOXP3+ Treg cells are consisted of naturally occurring, thymus-derived Treg (nTreg) and peripheral-induced Treg (iTreg) cells that may have different functional characteristics or synergistic roles. All-trans retinoic acid (atRA), a vitamin A metabolite, regulates a wide range of biological processes, including cell differentiation and proliferation. Recent studies demonstrated that atRA also regulates the differentiation of T helper (Th) cells and Treg cells. Moreover, atRA also sustains nTreg stability under inflammatory conditions. In this review, we summarize the significant progress of our understanding of the role(s) and mechanisms of atRA in Treg biology.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 553-557 |
| Number of pages | 5 |
| Journal | Cellular and Molecular Immunology |
| Volume | 12 |
| Issue number | 5 |
| DOIs | |
| State | Published - Sep 8 2015 |
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All Science Journal Classification (ASJC) codes
- Immunology and Allergy
- Immunology
- Infectious Diseases
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The role of all-trans retinoic acid in the biology of FOXP3+ regulatory T cells. / Liu, Zhong Min; Wang, Kun Peng; Ma, Jilin; Guo Zheng, Song.
In: Cellular and Molecular Immunology, Vol. 12, No. 5, 08.09.2015, p. 553-557.Research output: Contribution to journal › Review article
TY - JOUR
T1 - The role of all-trans retinoic acid in the biology of FOXP3+ regulatory T cells
AU - Liu, Zhong Min
AU - Wang, Kun Peng
AU - Ma, Jilin
AU - Guo Zheng, Song
PY - 2015/9/8
Y1 - 2015/9/8
N2 - Regulatory T (Treg) cells are necessary for immune system homeostasis and the prevention of autoimmune diseases. Foxp3 is specifically expressed in Treg cells and plays a key role in their differentiation and function. FOXP3+ Treg cells are consisted of naturally occurring, thymus-derived Treg (nTreg) and peripheral-induced Treg (iTreg) cells that may have different functional characteristics or synergistic roles. All-trans retinoic acid (atRA), a vitamin A metabolite, regulates a wide range of biological processes, including cell differentiation and proliferation. Recent studies demonstrated that atRA also regulates the differentiation of T helper (Th) cells and Treg cells. Moreover, atRA also sustains nTreg stability under inflammatory conditions. In this review, we summarize the significant progress of our understanding of the role(s) and mechanisms of atRA in Treg biology.
AB - Regulatory T (Treg) cells are necessary for immune system homeostasis and the prevention of autoimmune diseases. Foxp3 is specifically expressed in Treg cells and plays a key role in their differentiation and function. FOXP3+ Treg cells are consisted of naturally occurring, thymus-derived Treg (nTreg) and peripheral-induced Treg (iTreg) cells that may have different functional characteristics or synergistic roles. All-trans retinoic acid (atRA), a vitamin A metabolite, regulates a wide range of biological processes, including cell differentiation and proliferation. Recent studies demonstrated that atRA also regulates the differentiation of T helper (Th) cells and Treg cells. Moreover, atRA also sustains nTreg stability under inflammatory conditions. In this review, we summarize the significant progress of our understanding of the role(s) and mechanisms of atRA in Treg biology.
UR - http://www.scopus.com/inward/record.url?scp=84941125254&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84941125254&partnerID=8YFLogxK
U2 - 10.1038/cmi.2014.133
DO - 10.1038/cmi.2014.133
M3 - Review article
C2 - 25640656
AN - SCOPUS:84941125254
VL - 12
SP - 553
EP - 557
JO - Cellular and Molecular Immunology
JF - Cellular and Molecular Immunology
SN - 1672-7681
IS - 5
ER -