The role of all-trans retinoic acid in the biology of FOXP3+ regulatory T cells

Zhong Min Liu; Kun Peng Wang; Jilin Ma; Song Guo Zheng

doi:10.1038/cmi.2014.133

The role of all-trans retinoic acid in the biology of FOXP3⁺ regulatory T cells

Zhong Min Liu, Kun Peng Wang, Jilin Ma, Song Guo Zheng

Department of Medicine

Research output: Contribution to journal › Review article › peer-review

73 Scopus citations

Abstract

Regulatory T (Treg) cells are necessary for immune system homeostasis and the prevention of autoimmune diseases. Foxp3 is specifically expressed in Treg cells and plays a key role in their differentiation and function. FOXP3⁺ Treg cells are consisted of naturally occurring, thymus-derived Treg (nTreg) and peripheral-induced Treg (iTreg) cells that may have different functional characteristics or synergistic roles. All-trans retinoic acid (atRA), a vitamin A metabolite, regulates a wide range of biological processes, including cell differentiation and proliferation. Recent studies demonstrated that atRA also regulates the differentiation of T helper (Th) cells and Treg cells. Moreover, atRA also sustains nTreg stability under inflammatory conditions. In this review, we summarize the significant progress of our understanding of the role(s) and mechanisms of atRA in Treg biology.

Original language	English (US)
Pages (from-to)	553-557
Number of pages	5
Journal	Cellular and Molecular Immunology
Volume	12
Issue number	5
DOIs	https://doi.org/10.1038/cmi.2014.133
State	Published - Sep 8 2015

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Immunology
Infectious Diseases

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abstract = "Regulatory T (Treg) cells are necessary for immune system homeostasis and the prevention of autoimmune diseases. Foxp3 is specifically expressed in Treg cells and plays a key role in their differentiation and function. FOXP3+ Treg cells are consisted of naturally occurring, thymus-derived Treg (nTreg) and peripheral-induced Treg (iTreg) cells that may have different functional characteristics or synergistic roles. All-trans retinoic acid (atRA), a vitamin A metabolite, regulates a wide range of biological processes, including cell differentiation and proliferation. Recent studies demonstrated that atRA also regulates the differentiation of T helper (Th) cells and Treg cells. Moreover, atRA also sustains nTreg stability under inflammatory conditions. In this review, we summarize the significant progress of our understanding of the role(s) and mechanisms of atRA in Treg biology.",

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AB - Regulatory T (Treg) cells are necessary for immune system homeostasis and the prevention of autoimmune diseases. Foxp3 is specifically expressed in Treg cells and plays a key role in their differentiation and function. FOXP3+ Treg cells are consisted of naturally occurring, thymus-derived Treg (nTreg) and peripheral-induced Treg (iTreg) cells that may have different functional characteristics or synergistic roles. All-trans retinoic acid (atRA), a vitamin A metabolite, regulates a wide range of biological processes, including cell differentiation and proliferation. Recent studies demonstrated that atRA also regulates the differentiation of T helper (Th) cells and Treg cells. Moreover, atRA also sustains nTreg stability under inflammatory conditions. In this review, we summarize the significant progress of our understanding of the role(s) and mechanisms of atRA in Treg biology.

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The role of all-trans retinoic acid in the biology of FOXP3⁺ regulatory T cells

Abstract

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