The Role of C1-Esterase Inhibitors in the Management of Vasogenic Edema in Glioblastoma

Gillian R. Naro, Nicholas Noverati, Timothy Craig

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Glioblastoma (GB) is one of the most common adult primary brain tumors, classified as a grade IV astrocytoma and highly malignant in nature. As the tumor grows and disrupts the blood-brain barrier (BBB), vasogenic edema can result. The edema has the potential to significantly contribute to a patient's morbidity and mortality. Bradykinin has been theorized to play a role in this process as well as encourage tumor spread. Here we discuss a case in which a patient with vasogenic edema and angioedema refractory to antihistamines and high dose corticosteroids responded to C1-esterase inhibitor (C1INH) therapy. Though data exist concerning the role of bradykinin in GB, no clinical studies using C1INH have been done in humans with GB.

Original languageEnglish (US)
Article number7981609
JournalCase Reports in Medicine
Volume2020
DOIs
StatePublished - 2020

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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