The role of childhood trauma in the neurobiology of mood and anxiety disorders: Preclinical and clinical studies

Christine Marcelle Heim, Charles B. Nemeroff

Research output: Contribution to journalReview article

1775 Citations (Scopus)

Abstract

Epidemiologic studies indicate that children exposed to early adverse experiences are at increased risk for the development of depression, anxiety disorders, or both. Persistent sensitization of central nervous system (CNS) circuits as a consequence of early life stress, which are integrally involved in the regulation of stress and emotion, may represent the underlying biological substrate of an increased vulnerability to subsequent stress as well as to the development of depression and anxiety. A number of preclinical studies suggest that early life stress induces long-lived hyper(re)activity of corticotropin-releasing factor (CRF) systems as well as alterations in other neurotransmitter systems, resulting in increased stress responsiveness. Many of the findings from these preclinical studies are comparable to findings in adult patients with mood and anxiety disorders. Emerging evidence from clinical studies suggests that exposure to early life stress is associated with neurobiological changes in children and adults, which may underlie the increased risk of psychopathology. Current research is focused on strategies to prevent or reverse the detrimental effects of early life stress on the CNS. The identification of the neurobiological substrates of early adverse experience is of paramount importance for the development of novel treatments for children, adolescents, and adults.

Original languageEnglish (US)
Pages (from-to)1023-1039
Number of pages17
JournalBiological Psychiatry
Volume49
Issue number12
DOIs
StatePublished - Jun 15 2001

Fingerprint

Neurobiology
Anxiety Disorders
Mood Disorders
Psychological Stress
Wounds and Injuries
Depression
Central Nervous System Sensitization
Corticotropin-Releasing Hormone
Psychopathology
Neurotransmitter Agents
Epidemiologic Studies
Emotions
Anxiety
Central Nervous System
Clinical Studies
Research
Therapeutics

All Science Journal Classification (ASJC) codes

  • Biological Psychiatry

Cite this

@article{d62768c090f0423381fef9b78628a94e,
title = "The role of childhood trauma in the neurobiology of mood and anxiety disorders: Preclinical and clinical studies",
abstract = "Epidemiologic studies indicate that children exposed to early adverse experiences are at increased risk for the development of depression, anxiety disorders, or both. Persistent sensitization of central nervous system (CNS) circuits as a consequence of early life stress, which are integrally involved in the regulation of stress and emotion, may represent the underlying biological substrate of an increased vulnerability to subsequent stress as well as to the development of depression and anxiety. A number of preclinical studies suggest that early life stress induces long-lived hyper(re)activity of corticotropin-releasing factor (CRF) systems as well as alterations in other neurotransmitter systems, resulting in increased stress responsiveness. Many of the findings from these preclinical studies are comparable to findings in adult patients with mood and anxiety disorders. Emerging evidence from clinical studies suggests that exposure to early life stress is associated with neurobiological changes in children and adults, which may underlie the increased risk of psychopathology. Current research is focused on strategies to prevent or reverse the detrimental effects of early life stress on the CNS. The identification of the neurobiological substrates of early adverse experience is of paramount importance for the development of novel treatments for children, adolescents, and adults.",
author = "Heim, {Christine Marcelle} and Nemeroff, {Charles B.}",
year = "2001",
month = "6",
day = "15",
doi = "10.1016/S0006-3223(01)01157-X",
language = "English (US)",
volume = "49",
pages = "1023--1039",
journal = "Biological Psychiatry",
issn = "0006-3223",
publisher = "Elsevier USA",
number = "12",

}

The role of childhood trauma in the neurobiology of mood and anxiety disorders : Preclinical and clinical studies. / Heim, Christine Marcelle; Nemeroff, Charles B.

In: Biological Psychiatry, Vol. 49, No. 12, 15.06.2001, p. 1023-1039.

Research output: Contribution to journalReview article

TY - JOUR

T1 - The role of childhood trauma in the neurobiology of mood and anxiety disorders

T2 - Preclinical and clinical studies

AU - Heim, Christine Marcelle

AU - Nemeroff, Charles B.

PY - 2001/6/15

Y1 - 2001/6/15

N2 - Epidemiologic studies indicate that children exposed to early adverse experiences are at increased risk for the development of depression, anxiety disorders, or both. Persistent sensitization of central nervous system (CNS) circuits as a consequence of early life stress, which are integrally involved in the regulation of stress and emotion, may represent the underlying biological substrate of an increased vulnerability to subsequent stress as well as to the development of depression and anxiety. A number of preclinical studies suggest that early life stress induces long-lived hyper(re)activity of corticotropin-releasing factor (CRF) systems as well as alterations in other neurotransmitter systems, resulting in increased stress responsiveness. Many of the findings from these preclinical studies are comparable to findings in adult patients with mood and anxiety disorders. Emerging evidence from clinical studies suggests that exposure to early life stress is associated with neurobiological changes in children and adults, which may underlie the increased risk of psychopathology. Current research is focused on strategies to prevent or reverse the detrimental effects of early life stress on the CNS. The identification of the neurobiological substrates of early adverse experience is of paramount importance for the development of novel treatments for children, adolescents, and adults.

AB - Epidemiologic studies indicate that children exposed to early adverse experiences are at increased risk for the development of depression, anxiety disorders, or both. Persistent sensitization of central nervous system (CNS) circuits as a consequence of early life stress, which are integrally involved in the regulation of stress and emotion, may represent the underlying biological substrate of an increased vulnerability to subsequent stress as well as to the development of depression and anxiety. A number of preclinical studies suggest that early life stress induces long-lived hyper(re)activity of corticotropin-releasing factor (CRF) systems as well as alterations in other neurotransmitter systems, resulting in increased stress responsiveness. Many of the findings from these preclinical studies are comparable to findings in adult patients with mood and anxiety disorders. Emerging evidence from clinical studies suggests that exposure to early life stress is associated with neurobiological changes in children and adults, which may underlie the increased risk of psychopathology. Current research is focused on strategies to prevent or reverse the detrimental effects of early life stress on the CNS. The identification of the neurobiological substrates of early adverse experience is of paramount importance for the development of novel treatments for children, adolescents, and adults.

UR - http://www.scopus.com/inward/record.url?scp=0035875146&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035875146&partnerID=8YFLogxK

U2 - 10.1016/S0006-3223(01)01157-X

DO - 10.1016/S0006-3223(01)01157-X

M3 - Review article

C2 - 11430844

AN - SCOPUS:0035875146

VL - 49

SP - 1023

EP - 1039

JO - Biological Psychiatry

JF - Biological Psychiatry

SN - 0006-3223

IS - 12

ER -