Abstract
Epidemiologic studies indicate that children exposed to early adverse experiences are at increased risk for the development of depression, anxiety disorders, or both. Persistent sensitization of central nervous system (CNS) circuits as a consequence of early life stress, which are integrally involved in the regulation of stress and emotion, may represent the underlying biological substrate of an increased vulnerability to subsequent stress as well as to the development of depression and anxiety. A number of preclinical studies suggest that early life stress induces long-lived hyper(re)activity of corticotropin-releasing factor (CRF) systems as well as alterations in other neurotransmitter systems, resulting in increased stress responsiveness. Many of the findings from these preclinical studies are comparable to findings in adult patients with mood and anxiety disorders. Emerging evidence from clinical studies suggests that exposure to early life stress is associated with neurobiological changes in children and adults, which may underlie the increased risk of psychopathology. Current research is focused on strategies to prevent or reverse the detrimental effects of early life stress on the CNS. The identification of the neurobiological substrates of early adverse experience is of paramount importance for the development of novel treatments for children, adolescents, and adults.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1023-1039 |
| Number of pages | 17 |
| Journal | Biological Psychiatry |
| Volume | 49 |
| Issue number | 12 |
| DOIs | |
| State | Published - Jun 15 2001 |
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All Science Journal Classification (ASJC) codes
- Biological Psychiatry
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The role of childhood trauma in the neurobiology of mood and anxiety disorders : Preclinical and clinical studies. / Heim, Christine Marcelle; Nemeroff, Charles B.
In: Biological Psychiatry, Vol. 49, No. 12, 15.06.2001, p. 1023-1039.Research output: Contribution to journal › Review article
TY - JOUR
T1 - The role of childhood trauma in the neurobiology of mood and anxiety disorders
T2 - Preclinical and clinical studies
AU - Heim, Christine Marcelle
AU - Nemeroff, Charles B.
PY - 2001/6/15
Y1 - 2001/6/15
N2 - Epidemiologic studies indicate that children exposed to early adverse experiences are at increased risk for the development of depression, anxiety disorders, or both. Persistent sensitization of central nervous system (CNS) circuits as a consequence of early life stress, which are integrally involved in the regulation of stress and emotion, may represent the underlying biological substrate of an increased vulnerability to subsequent stress as well as to the development of depression and anxiety. A number of preclinical studies suggest that early life stress induces long-lived hyper(re)activity of corticotropin-releasing factor (CRF) systems as well as alterations in other neurotransmitter systems, resulting in increased stress responsiveness. Many of the findings from these preclinical studies are comparable to findings in adult patients with mood and anxiety disorders. Emerging evidence from clinical studies suggests that exposure to early life stress is associated with neurobiological changes in children and adults, which may underlie the increased risk of psychopathology. Current research is focused on strategies to prevent or reverse the detrimental effects of early life stress on the CNS. The identification of the neurobiological substrates of early adverse experience is of paramount importance for the development of novel treatments for children, adolescents, and adults.
AB - Epidemiologic studies indicate that children exposed to early adverse experiences are at increased risk for the development of depression, anxiety disorders, or both. Persistent sensitization of central nervous system (CNS) circuits as a consequence of early life stress, which are integrally involved in the regulation of stress and emotion, may represent the underlying biological substrate of an increased vulnerability to subsequent stress as well as to the development of depression and anxiety. A number of preclinical studies suggest that early life stress induces long-lived hyper(re)activity of corticotropin-releasing factor (CRF) systems as well as alterations in other neurotransmitter systems, resulting in increased stress responsiveness. Many of the findings from these preclinical studies are comparable to findings in adult patients with mood and anxiety disorders. Emerging evidence from clinical studies suggests that exposure to early life stress is associated with neurobiological changes in children and adults, which may underlie the increased risk of psychopathology. Current research is focused on strategies to prevent or reverse the detrimental effects of early life stress on the CNS. The identification of the neurobiological substrates of early adverse experience is of paramount importance for the development of novel treatments for children, adolescents, and adults.
UR - http://www.scopus.com/inward/record.url?scp=0035875146&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035875146&partnerID=8YFLogxK
U2 - 10.1016/S0006-3223(01)01157-X
DO - 10.1016/S0006-3223(01)01157-X
M3 - Review article
C2 - 11430844
AN - SCOPUS:0035875146
VL - 49
SP - 1023
EP - 1039
JO - Biological Psychiatry
JF - Biological Psychiatry
SN - 0006-3223
IS - 12
ER -